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Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
Tang, JM; He, QY; Guo, RX; Chang, XJ
关键词Akt Pten Non-small Cell Lung Cancer Immunohistochemistry Cell Cycle Regulation Prognosis
刊名LUNG CANCER
2006-02-01
DOI10.1016/j.lungcan.2005.10.003
51期:2页:181-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Respiratory System
研究领域[WOS]Oncology ; Respiratory System
关键词[WOS]TUMOR-SUPPRESSOR PTEN ; PROTEIN-KINASE-B ; PHOSPHATIDYLINOSITOL 3-KINASE/AKT PATHWAY ; LIPID PHOSPHATASE-ACTIVITY ; FOCAL ADHESION KINASE ; BREAST-CANCER ; CHEMOTHERAPEUTIC RESISTANCE ; PROSTATE-CANCER ; SURVIVAL ; ACTIVATION
英文摘要

Akt, a downstream mediator of phosphatidylinositol 3-kinase (PI3K), is a signal transduction protein that plays a central role in tumorigenesis. The tumor suppressor gene PTEN negatively regulates the PI3K/Akt signaling pathway. However, the roles of At and PTEN function in patients with non-small cell lung cancer (NSCLC) is not well established. To clarify roles of expression of phosphorylated At (p-Akt) and toss of PTEN expression in biological behavior and prognosis of NSCLC. Immunohistochemical staining was used to determine the expression of p-Akt and PTEN in 20 cases of normal lung tissues and 102 cases patients with NSCLC. ALL patients with NSCLC were followed from 3 to 60 months. The positive incidence of p-Akt expression and Loss incidence of PTEN expression in NSCLC were 41.2% (42/102) and 46.1% (47/102), while negative of p-Akt expression (0%, 0/20) and positive of PTEN expression (100%, 20/20) in normal lung tissues. Overexpression of p-Akt and Loss of PTEN expression were correlated to poor differentiation, lymph node involvement, distant metastasis and late stages. A significant negative correlation was observed between expression of p-Akt and PTEN (r = -0.425, P < 0.001). Patients with p-Akt positive expression (42/102) and loss of PTEN expression (47/102) showed significantly worse 5 years survival rate and median survival time than relevant those with p-Akt negative expression (14.29% versus 33.33%, 14 months versus 32 months, Logrank test chi(2) = 14.24, P < 0.001) and PTEN positive expression (10.64% versus 38.18%, 15 months versus 40 months, Log-rank test chi(2) = 21.06, P < 0.001). A univariate analysis revealed that smoking, tumor size, lymph node involvement, distant metastasis, stage, p-Akt and loss of PTEN expression were significant correlative factors with prognosis. The result of multivariate Cox analysis showed that smoking, stage and loss of PTEN expression were independent prognosticators. p-Akt is overexpressed and accompanied by the loss of PTEN in clinical specimens of NSCLC. Both p-Akt and PTEN are concerned with invasion and metastasis of NSCLC. Loss of PTEN expression is an independent poor prognostic factor for patients with NSCLC. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000235564000004
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被引频次:243[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56587
专题北京大学第二临床医学院
作者单位1.Beijing TB & Thorac Tumor Res Inst, Beijing 101149, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Resp, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Gynecol, Beijing 100044, Peoples R China
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GB/T 7714
Tang, JM,He, QY,Guo, RX,et al. Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis[J]. LUNG CANCER,2006,51(2):181-191.
APA Tang, JM,He, QY,Guo, RX,&Chang, XJ.(2006).Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis.LUNG CANCER,51(2),181-191.
MLA Tang, JM,et al."Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis".LUNG CANCER 51.2(2006):181-191.
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