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学科主题临床医学
Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome
Zhang, Qingyou1; Chen, Xia2; Li, Jiawei1; Du, Junbao1,3
关键词Norepinephrine Postural Tachycardia Syndrome Metoprolol
刊名JOURNAL OF TRANSLATIONAL MEDICINE
2014-09-10
DOI10.1186/s12967-014-0249-3
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者Beijing Municipal Science &amp ; Technology Commission ; National Twelfth 5-year Plan for Science and Technology Support ; Beijing Municipal Science &amp ; Technology Commission ; National Twelfth 5-year Plan for Science and Technology Support
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]QUALITY-OF-LIFE ; MIDODRINE HYDROCHLORIDE ; EXERCISE CAPACITY ; INTOLERANCE ; PROPRANOLOL ; ADOLESCENTS
英文摘要

Background: Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of this study is to explore whether orthostatic plasma norepinephrine level could be an indicator of therapeutic effectiveness of metoprolol for POTS in children.

Methods: Twenty-seven children with POTS were enrolled in our study. They received metoprolol treatment, and their orthostatic plasma norepinephrine levels were measured by high-performance liquid chromatography method. Three months after rmetoprolol treatment, 25 patients were followed up. A receiver-operating characteristic (ROC) curve was used to explore the predictive value of orthostatic plasma norepinephrine level.

Results: The symptom severity and increment of heat rate from supine position to upright of patients positively correlated with their orthostatic plasma norepinephrine level (r = 0.599, P < 0.001; r = 0.633, P < 0.001, respectively). Orthostatic plasma norepinephrine level in responders to metoprolol was significantly higher than that of nonresponders (P = 0.028). A ROC curve on the predictive value of orthostatic plasma norepinephrine level showed that the area under the curve was 0.785. Using a cutoff value for orthostatic plasma norepinephrine level of 3.59 pg/ml yielded both sensitivity (76.9%) and specificity (91.7%) in predicting the efficacy of metoprolol therapy for POTS.

Conclusion: Orthostatic plasma norepinephrine level of > 3.59 pg/ml was an indicator of the effectiveness of metoprolol therapy for POTS in children and adolescents.

语种英语
所属项目编号D121107001012051 ; 2012BAI03B03
资助者Beijing Municipal Science &amp ; Technology Commission ; National Twelfth 5-year Plan for Science and Technology Support ; Beijing Municipal Science &amp ; Technology Commission ; National Twelfth 5-year Plan for Science and Technology Support
WOS记录号WOS:000342174500002
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56593
专题北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiol, Beijing 100019, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Langfang Municipal Peoples Hosp, Dept Pediat, Langfang 065000, Hebei, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Qingyou,Chen, Xia,Li, Jiawei,et al. Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
APA Zhang, Qingyou,Chen, Xia,Li, Jiawei,&Du, Junbao.(2014).Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome.JOURNAL OF TRANSLATIONAL MEDICINE,12.
MLA Zhang, Qingyou,et al."Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome".JOURNAL OF TRANSLATIONAL MEDICINE 12(2014).
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