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学科主题: 临床医学
题名:
Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome
作者: Zhang, Qingyou1; Chen, Xia2; Li, Jiawei1; Du, Junbao1,3
关键词: Norepinephrine ; Postural tachycardia syndrome ; Metoprolol
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2014-09-10
DOI: 10.1186/s12967-014-0249-3
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: QUALITY-OF-LIFE ; MIDODRINE HYDROCHLORIDE ; EXERCISE CAPACITY ; INTOLERANCE ; PROPRANOLOL ; ADOLESCENTS
英文摘要:

Background: Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of this study is to explore whether orthostatic plasma norepinephrine level could be an indicator of therapeutic effectiveness of metoprolol for POTS in children.

Methods: Twenty-seven children with POTS were enrolled in our study. They received metoprolol treatment, and their orthostatic plasma norepinephrine levels were measured by high-performance liquid chromatography method. Three months after rmetoprolol treatment, 25 patients were followed up. A receiver-operating characteristic (ROC) curve was used to explore the predictive value of orthostatic plasma norepinephrine level.

Results: The symptom severity and increment of heat rate from supine position to upright of patients positively correlated with their orthostatic plasma norepinephrine level (r = 0.599, P < 0.001; r = 0.633, P < 0.001, respectively). Orthostatic plasma norepinephrine level in responders to metoprolol was significantly higher than that of nonresponders (P = 0.028). A ROC curve on the predictive value of orthostatic plasma norepinephrine level showed that the area under the curve was 0.785. Using a cutoff value for orthostatic plasma norepinephrine level of 3.59 pg/ml yielded both sensitivity (76.9%) and specificity (91.7%) in predicting the efficacy of metoprolol therapy for POTS.

Conclusion: Orthostatic plasma norepinephrine level of > 3.59 pg/ml was an indicator of the effectiveness of metoprolol therapy for POTS in children and adolescents.

语种: 英语
所属项目编号: D121107001012051 ; 2012BAI03B03
项目资助者: Beijing Municipal Science &amp ; Technology Commission ; National Twelfth 5-year Plan for Science and Technology Support
WOS记录号: WOS:000342174500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56593
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiol, Beijing 100019, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Langfang Municipal Peoples Hosp, Dept Pediat, Langfang 065000, Hebei, Peoples R China

Recommended Citation:
Zhang, Qingyou,Chen, Xia,Li, Jiawei,et al. Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
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