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学科主题口腔医学
Isoproterenol Improves Secretion of Transplanted Submandibular Glands
Li, Y. M.1,2,6; Zhang, Y.1,2; Shi, L.3,4; Xiang, B.3,4; Cong, X.1,2; Zhang, Y. Y.5; Wu, L. L.1,2; Yu, G. Y.3,4
关键词Beta-adrenoceptor Isoproterenol Rabbit Submandibular Gland Transplantation
刊名JOURNAL OF DENTAL RESEARCH
2009-05-01
DOI10.1177/0022034509337114
88期:5页:477-482
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BETA-ADRENERGIC RECEPTORS ; KERATOCONJUNCTIVITIS SICCA ; SALIVARY-GLAND ; CELL-PROLIFERATION ; DRY-EYE ; EXPRESSION ; APOPTOSIS ; DIAGNOSIS ; SYSTEMS
英文摘要

Autotransplantation of the submandibular gland is effective for severe keratoconjunctivitis sicca. However, most transplants show decreased secretion shortly after the operation, which leads to obstruction of Wharton′s duct. The hypothesis that decreased catecholamine release due to denervation contributes to hypofunction in the early phase was tested in transplanted glands in rabbits. We found that salivary flow, expression of beta(1)- and beta(2)-adrenoceptor, and the maximum binding capacity were markedly decreased in the transplanted glands. Isoproterenol significantly reversed the decreased secretion, enhanced the expressions of beta(1)- and beta(2)-adrenoceptor, and ameliorated the atrophy of acinar cells. The contents of cAMP and phospho-ERK 1/2 were increased after isoproterenol treatment. These results indicate that lack of beta-adrenoceptor stimulation is involved in early dysfunction of the transplanted gland. Isoproterenol treatment moderates structural injury and improves secretory function in the transplanted submandibular gland through up-regulating beta(1)-and beta(2)-adrenoceptor expression and post-receptor signal transduction.

语种英语
WOS记录号WOS:000266624600016
项目编号30730102 ; 2007BAI18B11 ; 2005-2009
资助机构National Nature Science Foundation of China ; National Supporting Program for Science and Technology ; Capital Medical Development Foundation ; Program for Changjiang Scholars and Innovative Research Team in University
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56594
专题北京大学口腔医学院
北京大学基础医学院
作者单位1.Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
5.Peking Univ, Dept Oral & Maxillofacial Surg, Hosp Stomatol, Beijing 100081, Peoples R China
6.Capital Med Univ, Yanjing Med Coll, Dept Physiol & Pathophysiol, Beijing, Peoples R China
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GB/T 7714
Li, Y. M.,Zhang, Y.,Shi, L.,et al. Isoproterenol Improves Secretion of Transplanted Submandibular Glands[J]. JOURNAL OF DENTAL RESEARCH,2009,88(5):477-482.
APA Li, Y. M..,Zhang, Y..,Shi, L..,Xiang, B..,Cong, X..,...&Yu, G. Y..(2009).Isoproterenol Improves Secretion of Transplanted Submandibular Glands.JOURNAL OF DENTAL RESEARCH,88(5),477-482.
MLA Li, Y. M.,et al."Isoproterenol Improves Secretion of Transplanted Submandibular Glands".JOURNAL OF DENTAL RESEARCH 88.5(2009):477-482.
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