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学科主题: 口腔医学
题名:
Isoproterenol Improves Secretion of Transplanted Submandibular Glands
作者: Li, Y. M.1,2,6; Zhang, Y.1,2; Shi, L.3,4; Xiang, B.3,4; Cong, X.1,2; Zhang, Y. Y.5; Wu, L. L.1,2; Yu, G. Y.3,4
关键词: beta-adrenoceptor ; isoproterenol ; rabbit ; submandibular gland ; transplantation
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2009-05-01
DOI: 10.1177/0022034509337114
卷: 88, 期:5, 页:477-482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: BETA-ADRENERGIC RECEPTORS ; KERATOCONJUNCTIVITIS SICCA ; SALIVARY-GLAND ; CELL-PROLIFERATION ; DRY-EYE ; EXPRESSION ; APOPTOSIS ; DIAGNOSIS ; SYSTEMS
英文摘要:

Autotransplantation of the submandibular gland is effective for severe keratoconjunctivitis sicca. However, most transplants show decreased secretion shortly after the operation, which leads to obstruction of Wharton′s duct. The hypothesis that decreased catecholamine release due to denervation contributes to hypofunction in the early phase was tested in transplanted glands in rabbits. We found that salivary flow, expression of beta(1)- and beta(2)-adrenoceptor, and the maximum binding capacity were markedly decreased in the transplanted glands. Isoproterenol significantly reversed the decreased secretion, enhanced the expressions of beta(1)- and beta(2)-adrenoceptor, and ameliorated the atrophy of acinar cells. The contents of cAMP and phospho-ERK 1/2 were increased after isoproterenol treatment. These results indicate that lack of beta-adrenoceptor stimulation is involved in early dysfunction of the transplanted gland. Isoproterenol treatment moderates structural injury and improves secretory function in the transplanted submandibular gland through up-regulating beta(1)-and beta(2)-adrenoceptor expression and post-receptor signal transduction.

语种: 英语
所属项目编号: 30730102 ; 2007BAI18B11 ; 2005-2009
项目资助者: National Nature Science Foundation of China ; National Supporting Program for Science and Technology ; Capital Medical Development Foundation ; Program for Changjiang Scholars and Innovative Research Team in University
WOS记录号: WOS:000266624600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56594
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
5.Peking Univ, Dept Oral & Maxillofacial Surg, Hosp Stomatol, Beijing 100081, Peoples R China
6.Capital Med Univ, Yanjing Med Coll, Dept Physiol & Pathophysiol, Beijing, Peoples R China

Recommended Citation:
Li, Y. M.,Zhang, Y.,Shi, L.,et al. Isoproterenol Improves Secretion of Transplanted Submandibular Glands[J]. JOURNAL OF DENTAL RESEARCH,2009,88(5):477-482.
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