学科主题临床医学
Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns
Pan, X. B.; Wei, L.; Chen, H. S.; Liu, F.; Gao, Y.
刊名ARCHIVES OF VIROLOGY
2007-06-01
DOI10.1007/s00705-006-0927-4
152期:6页:1159-1173
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]HEPATITIS-B-VIRUS ; NUCLEAR RECEPTOR SUPERFAMILY ; SURFACE-ANTIGEN PROMOTER ; TRANSCRIPTION FACTOR ; BINDING-SITE ; GENE-EXPRESSION ; CORE PROMOTER ; EGF RECEPTOR ; ENHANCER II ; X-PROTEIN
英文摘要

Hepatitis B virus (HBV) infection is currently still a worldwide heath concern. In our study, we compared HBV replication patterns in two liver-derived cell lines, QSG-7701 and HepG2. Viral markers of HBV replication in culture medium and cells were analyzed after transfection of these cells with plasmid pUC18-HBV1.2 into. We showed that QSG-7701 cells could support more stable and a higher level of HBV replication than HepG2 cells. Gene expression profiles of QSG-7701 and HepG2 cells by microarray analysis showed that many genes were differentially expressed between these two cell lines, including those that are related to the HBV life cycle. The global gene expression profile of these two cell types provides some clues to explain how different HBV replication is achieved. QSG-7701 cells offer a new opportunity for basic research on HBV virus-host interactions.

语种英语
WOS记录号WOS:000246747500011
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56595
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Pan, X. B.,Wei, L.,Chen, H. S.,et al. Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns[J]. ARCHIVES OF VIROLOGY,2007,152(6):1159-1173.
APA Pan, X. B.,Wei, L.,Chen, H. S.,Liu, F.,&Gao, Y..(2007).Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns.ARCHIVES OF VIROLOGY,152(6),1159-1173.
MLA Pan, X. B.,et al."Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns".ARCHIVES OF VIROLOGY 152.6(2007):1159-1173.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Pan, X. B.]的文章
[Wei, L.]的文章
[Chen, H. S.]的文章
百度学术
百度学术中相似的文章
[Pan, X. B.]的文章
[Wei, L.]的文章
[Chen, H. S.]的文章
必应学术
必应学术中相似的文章
[Pan, X. B.]的文章
[Wei, L.]的文章
[Chen, H. S.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。