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学科主题: 临床医学
题名:
Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns
作者: Pan, X. B.; Wei, L.; Chen, H. S.; Liu, F.; Gao, Y.
刊名: ARCHIVES OF VIROLOGY
发表日期: 2007-06-01
DOI: 10.1007/s00705-006-0927-4
卷: 152, 期:6, 页:1159-1173
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-B-VIRUS ; NUCLEAR RECEPTOR SUPERFAMILY ; SURFACE-ANTIGEN PROMOTER ; TRANSCRIPTION FACTOR ; BINDING-SITE ; GENE-EXPRESSION ; CORE PROMOTER ; EGF RECEPTOR ; ENHANCER II ; X-PROTEIN
英文摘要:

Hepatitis B virus (HBV) infection is currently still a worldwide heath concern. In our study, we compared HBV replication patterns in two liver-derived cell lines, QSG-7701 and HepG2. Viral markers of HBV replication in culture medium and cells were analyzed after transfection of these cells with plasmid pUC18-HBV1.2 into. We showed that QSG-7701 cells could support more stable and a higher level of HBV replication than HepG2 cells. Gene expression profiles of QSG-7701 and HepG2 cells by microarray analysis showed that many genes were differentially expressed between these two cell lines, including those that are related to the HBV life cycle. The global gene expression profile of these two cell types provides some clues to explain how different HBV replication is achieved. QSG-7701 cells offer a new opportunity for basic research on HBV virus-host interactions.

语种: 英语
WOS记录号: WOS:000246747500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56595
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Pan, X. B.,Wei, L.,Chen, H. S.,et al. Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns[J]. ARCHIVES OF VIROLOGY,2007,152(6):1159-1173.
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