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学科主题: 临床医学
题名:
Abnormal lipid metabolism down-regulates adenosine triphosphate synthase beta-subunit protein expression in corpus cavernosum smooth muscle in vitro and in vivo
作者: Liu, Z. -H.1; Yu, L. -P.1; Xu, T.1; Zhang, X. -W.1; Yuan, Y. -Q.1; Xiao, Y. -B.1; Li, J.1; Hao, Y. -C.1; Zhao, Y. -P.2; Wang, X. -F.1
关键词: ATP synthase ; cavernosum smooth muscle ; erectile dysfunction ; lipid metabolism
刊名: ANDROLOGIA
发表日期: 2014-06-01
DOI: 10.1111/and.12105
卷: 46, 期:5, 页:487-494
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: HUMAN SKELETAL-MUSCLE ; ATP SYNTHASE ; ERECTILE DYSFUNCTION ; NITRIC-OXIDE ; FATTY-ACIDS ; DIABETIC-RATS ; INHIBITION ; CELLS ; ACTIVATION ; GLUCOSE
英文摘要:

Metabolic syndrome is closely related to erectile dysfunction (ED), and hyperlipidaemia is considered a major risk factor for ED. Adenosine triphosphate (ATP) synthase is believed to play an important role in metabolic syndrome; it has been hypothesised that ATP synthase contributes to ED development. We have verified this hypothesis using primary cultured human corpus cavernosum smooth muscle (HCCSM) cells treated with excessive free fat acid (FFA) and a high-fat diet (HFD) mouse model. Our results showed that high fatty factors could cause lipid accumulation in HCCSM cells, which could result in abnormal lipid metabolism, such as high levels of triglycerides, cholesterol and glucose in the HFD mice. There was a remarkable down-regulation of ATP synthase and p-Akt after in vivo and in vitro excessive FFA treatments. These results indicated that abnormal lipid metabolism could induce ATP synthase down-regulation via the Akt phosphorylation pathway and that ATP synthase may be a target of lipotoxicity in corpus cavernosum smooth muscle cells.

语种: 英语
WOS记录号: WOS:000335009600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56609
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Z. -H.,Yu, L. -P.,Xu, T.,et al. Abnormal lipid metabolism down-regulates adenosine triphosphate synthase beta-subunit protein expression in corpus cavernosum smooth muscle in vitro and in vivo[J]. ANDROLOGIA,2014,46(5):487-494.
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