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IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科  > 期刊论文
学科主题: 临床医学
题名:
Proposal of a new lymph node staging system for gastric cancer: study from two institutions in China
作者: Zhang, Jizhun1; Jiang, Kewei1; Liu, Yong2; Ye, Yingjiang1; Lv, Liang1,3; Shen, Zhanlong1; Zhou, Yangbing3; Wang, Shan1
关键词: Gastric cancer ; TNM classification ; Prognosis ; AJCC
刊名: MEDICAL ONCOLOGY
发表日期: 2014-10-01
DOI: 10.1007/s12032-014-0229-8
卷: 31, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: AMERICAN JOINT COMMITTEE ; 7TH EDITION ; TNM CLASSIFICATION ; ADENOCARCINOMA ; VALIDATION
英文摘要:

The aim of this study was to identify the best cutoff points for lymph node classification to improve the prognostic prediction of gastric cancer in China. Patients who had undergone surgery for gastric cancer were retrospectively evaluated in two high-volume institutions from Peking University People′s Hospital (PKUPH, N = 503) and Affiliated Hospital of Qingdao University (AHQU, N = 1,003). The prognosis of these patients was assessed according to the number of metastatic lymph nodes with an increment of one node at one time. A new lymph node classification was proposed based on the relation between prognosis and the number of metastatic lymph nodes. According to the prognostic value, the proposed node (N) stage was categorized as N-0 (no regional LNs metastasis), N-1 (1-3 involved regional LNs), N-2 (4-6 involved regional LNs), and N-3 (>= 7 involved regional LNs). The hazard ratio for the proposed N classification increased steadily and reasonably compared with the 7th edition. Moreover, the Cox regression multivariate analysis showed that the proposed N classification was superior to the 7th N classification as an independent prognostic factor. The proposed N category was superior to 7th edition N category of the American Joint Committee on Cancer (AJCC) for assessing the prognosis for gastric cancer patients in China.

语种: 英语
所属项目编号: 81372290 ; 81372291
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000342079600044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56612
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Zhangqiu Hosp Tradit Chinese Med, Dept Gen Surg, Jinan, Shandong, Peoples R China
3.QingDao Univ, Affiliated Hosp, Dept Gen Surg, Qingdao 266000, Peoples R China

Recommended Citation:
Zhang, Jizhun,Jiang, Kewei,Liu, Yong,et al. Proposal of a new lymph node staging system for gastric cancer: study from two institutions in China[J]. MEDICAL ONCOLOGY,2014,31(10).
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