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IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis
作者: Sun, Yi; Liu, Wei; Wan, Zhe; Wang, Xiaohong; Li, Ruoyu
关键词: Antifungal activity ; Drug combinations ; Exophiala dermatitidis ; Phaeohyphomycosis
刊名: MYCOPATHOLOGIA
发表日期: 2011-02-01
DOI: 10.1007/s11046-010-9358-6
卷: 171, 期:2, 页:111-117
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: AMPHOTERICIN-B ; CYSTIC-FIBROSIS ; DEMATIACEOUS FUNGI ; CASPOFUNGIN ; PHEOHYPHOMYCOSIS ; ASPERGILLOSIS ; VORICONAZOLE ; PATIENT ; ITRACONAZOLE ; ECHINOCANDIN
英文摘要:

To evaluate the in vitro efficacy of common antifungal drugs, as well as the interactions of caspofungin with voriconazole, amphotericin B, or itraconazole against the pathogenic black yeast Exophiala dermatitidis from China, the minimal inhibitory concentrations (MICs) of terbinafine, voriconazole, itraconazole, amphotericin B, fluconazole, and caspofungin against 16 strains of E. dermatitidis were determined by using CLSI broth microdilution method (M38-A2). The minimal fungicidal concentrations (MFCs) were also determined. Additionally, the interactions of caspofungin with voriconazole, amphotericin B, itraconazole or fluconazole, that of terbinafine with itraconazole, or that of fluconazole with amphotericin B were assessed by using the checkerboard technique. The fractional inhibitory concentration index (FICI) was used to categorize drug interactions as following, synergy, FICI a parts per thousand currency sign 0.5; indifference, FICI > 0.5 and a parts per thousand currency sign4.0; or antagonism, FICI > 4.0. The MIC ranges of terbinafine, voriconazole, itraconazole, amphotericin B, fluconazole, and caspofungin against E. dermatitidis were 0.06-0.125 mg/l, 0.25-1.0 mg/l, 1.0-2.0 mg/l, 1.0-2.0 mg/l, 16-64 mg/l, and 32-64 mg/l, respectively. The in vitro interactions of caspofungin with voriconazole, amphotericin B, and itraconazole showed synergic effect against 10/16(62.5%), 15/16(93.75%), and 16/16(100%) isolates, while that of caspofungin with fluconazole showed indifference. Besides, the interaction of terbinafine with itraconazole as well as that of fluconazole with amphotericin B showed indifference. Terbinafine, voriconazole, itraconazole, and amphotericin B have good activity against E. dermatitidis. The combinations of caspofungin with voriconazole, amphotericin B or itraconazole present synergic activity against E. dermatitidis. These results provide the basis for novel options in treating various E. dermatitidis infections.

语种: 英语
所属项目编号: 30970131 ; 107002
项目资助者: National Natural Science Foundation of China ; Chinese Ministry of Education
WOS记录号: WOS:000286103500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56614
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China

Recommended Citation:
Sun, Yi,Liu, Wei,Wan, Zhe,et al. Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis[J]. MYCOPATHOLOGIA,2011,171(2):111-117.
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