IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis
Sun, Yi; Liu, Wei; Wan, Zhe; Wang, Xiaohong; Li, Ruoyu
关键词Antifungal Activity Drug Combinations Exophiala Dermatitidis Phaeohyphomycosis
刊名MYCOPATHOLOGIA
2011-02-01
DOI10.1007/s11046-010-9358-6
171期:2页:111-117
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]AMPHOTERICIN-B ; CYSTIC-FIBROSIS ; DEMATIACEOUS FUNGI ; CASPOFUNGIN ; PHEOHYPHOMYCOSIS ; ASPERGILLOSIS ; VORICONAZOLE ; PATIENT ; ITRACONAZOLE ; ECHINOCANDIN
英文摘要

To evaluate the in vitro efficacy of common antifungal drugs, as well as the interactions of caspofungin with voriconazole, amphotericin B, or itraconazole against the pathogenic black yeast Exophiala dermatitidis from China, the minimal inhibitory concentrations (MICs) of terbinafine, voriconazole, itraconazole, amphotericin B, fluconazole, and caspofungin against 16 strains of E. dermatitidis were determined by using CLSI broth microdilution method (M38-A2). The minimal fungicidal concentrations (MFCs) were also determined. Additionally, the interactions of caspofungin with voriconazole, amphotericin B, itraconazole or fluconazole, that of terbinafine with itraconazole, or that of fluconazole with amphotericin B were assessed by using the checkerboard technique. The fractional inhibitory concentration index (FICI) was used to categorize drug interactions as following, synergy, FICI a parts per thousand currency sign 0.5; indifference, FICI > 0.5 and a parts per thousand currency sign4.0; or antagonism, FICI > 4.0. The MIC ranges of terbinafine, voriconazole, itraconazole, amphotericin B, fluconazole, and caspofungin against E. dermatitidis were 0.06-0.125 mg/l, 0.25-1.0 mg/l, 1.0-2.0 mg/l, 1.0-2.0 mg/l, 16-64 mg/l, and 32-64 mg/l, respectively. The in vitro interactions of caspofungin with voriconazole, amphotericin B, and itraconazole showed synergic effect against 10/16(62.5%), 15/16(93.75%), and 16/16(100%) isolates, while that of caspofungin with fluconazole showed indifference. Besides, the interaction of terbinafine with itraconazole as well as that of fluconazole with amphotericin B showed indifference. Terbinafine, voriconazole, itraconazole, and amphotericin B have good activity against E. dermatitidis. The combinations of caspofungin with voriconazole, amphotericin B or itraconazole present synergic activity against E. dermatitidis. These results provide the basis for novel options in treating various E. dermatitidis infections.

语种英语
WOS记录号WOS:000286103500004
项目编号30970131 ; 107002
资助机构National Natural Science Foundation of China ; Chinese Ministry of Education
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56614
专题北京大学第一临床医学院_皮肤性病科
北京大学第三临床医学院_药剂科
作者单位Peking Univ, Hosp 1, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Sun, Yi,Liu, Wei,Wan, Zhe,et al. Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis[J]. MYCOPATHOLOGIA,2011,171(2):111-117.
APA Sun, Yi,Liu, Wei,Wan, Zhe,Wang, Xiaohong,&Li, Ruoyu.(2011).Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis.MYCOPATHOLOGIA,171(2),111-117.
MLA Sun, Yi,et al."Antifungal Activity of Antifungal Drugs, as Well as Drug Combinations Against Exophiala dermatitidis".MYCOPATHOLOGIA 171.2(2011):111-117.
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