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学科主题: 临床医学
题名:
SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors
作者: Li, Zhongwu1; Yuan, Jing2; Wei, Lixin2; Zhou, Lixin1; Mei, Kaiyong3; Yue, Junqiu4; Gao, Hongwen5; Zhang, Miao1; Jia, Ling1; Kang, Qiang1; Huang, Xiaozheng1; Cao, Dengfeng1,6
关键词: SATB2 ; well-differentiated neuroendocrine tumor ; foregut ; midgut ; hindgut
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:6, 页:7072-7082
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: PANCREATIC ENDOCRINE TUMORS ; PROSTATIC ACID-PHOSPHATASE ; PULMONARY CARCINOID-TUMORS ; TRANSCRIPTION FACTOR-I ; SMALL-CELL CARCINOMAS ; PAX8 EXPRESSION ; IMMUNOHISTOCHEMICAL PANEL ; PROGNOSTIC-FACTORS ; ISL1 EXPRESSION ; UNKNOWN PRIMARY
英文摘要:

Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas. The goal of this study was to investigate the expression of SATB2 in well-differentiated neuroendocrine tumors to explore its potential as a diagnostic marker for hindgut well-differentiated neuroendocrine tumors. Immunohistochemical staining with a monoclonal antibody to SATB2 was performed on full tissue blocks in 167 well-differentiated neuroendocrine tumors of various origins. The staining was semi-quantitatively scored as 0 (no tumor cell staining), 1+ (1-25%), 2+ (26-50%), 3+ (51-75%) and 4+ (76-100%). Positive SATB2 staining was seen in 17% foregut (14/84, 12/66 primary and 2/18 metastatic), 12% midgut (3/22, 3/18 primary and 0/7 metastatic), and 90% hindgut (52/58, 44/49 primary and 8/9 metastatic) well differentiated neuroendocrine tumors. Most hindgut well-differentiated neuroendocrine tumors (41/58) showed 4+ staining. The specificity of SATB2 for foregut, midgut and hindgut well-differentiated neuroendocrine tumors was 34%, 54% and 84%, respectively. Our results indicate that SATB2 is a sensitive marker for hindgut well-differentiated neuroendocrine tumors though it is not entirely specific. SATB2 should be included in the immunohistochemical panel in working out metastatic well-differentiated neuroendocrine tumor of an unknown origin.

语种: 英语
所属项目编号: 12-01 ; 2012-FC-TSYS-3050 ; 2012B033
项目资助者: Peking University Cancer Hospital Institute ; Beijing Health and Family Planning Commission ; Clinical Science Fund of the Chinese PLA General Hospital ; Beijing Municipal Science and Technology Commission NOVA Program Fund
WOS记录号: WOS:000359277700123
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56615
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Hubei Canc Hosp, Dept Pathol, Wuhan, Peoples R China
2.Peking Univ, Canc Hosp, Minist Educ,Beijing Canc Hosp, Dept Pathol,Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
4.Guangzhou Med Univ, Dept Pathophysiol, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
5.Jilin Univ, Dept Pathol, Affiliated Hosp 2, Changchun 130023, Peoples R China
6.Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63017 USA

Recommended Citation:
Li, Zhongwu,Yuan, Jing,Wei, Lixin,et al. SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(6):7072-7082.
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