IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Hormonal therapy in ovarian cancer
Zheng, H.; Kavanagh, J. J.; Hu, W.; Liao, Q.; Fu, S.
关键词Androgen Estrogen Gonadotropin Gonadotropin-releasing Hormone Hormonal Therapy Ovarian Cancer Progesterone
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2007-03-01
DOI10.1111/j.1525-1438.2006.00749.x
17期:2页:325-338
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]GONADOTROPIN-RELEASING-HORMONE ; PHASE-II TRIAL ; SURFACE EPITHELIAL-CELLS ; ESTROGEN REPLACEMENT THERAPY ; DOSE MEGESTROL-ACETATE ; GYNECOLOGIC-ONCOLOGY-GROUP ; ACTIVATED PROTEIN-KINASE ; MESSENGER-RIBONUCLEIC-ACID ; EPIDERMAL-GROWTH-FACTOR ; AGONIST ANALOG THERAPY
英文摘要

Ovarian carcinoma continues to be the leading cause of death due to gynecological malignancy. Epidemiologic studies indicate that steroid hormones play roles in ovarian carcinogenesis. Gonadotropins, estrogen, and androgen may be causative factors, while gonadotropin-releasing hormone and progesterone may be protective factors in ovarian cancer pathogenesis. Experimental studies have shown that hormonal receptors are expressed in ovarian cancer cells and mediate the growth-stimulatory or growth-inhibitory effects of the hormones on these cells. Hormonal therapeutic agents have been evaluated in several clinical trials. Most of these trials were conducted in patients with recurrent or refractory ovarian cancer, with modest efficacy and few side effects. Better understanding of the mechanisms through which hormones affect cell growth may improve the efficacy of hormonal therapy. Molecular markers that can reliably predict major clinical outcomes should be investigated further in well-designed trials.

语种英语
WOS记录号WOS:000244885300003
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56616
专题北京大学第一临床医学院
作者单位1.Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77230 USA
2.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Med Oncol, Houston, TX 77230 USA
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GB/T 7714
Zheng, H.,Kavanagh, J. J.,Hu, W.,et al. Hormonal therapy in ovarian cancer[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2007,17(2):325-338.
APA Zheng, H.,Kavanagh, J. J.,Hu, W.,Liao, Q.,&Fu, S..(2007).Hormonal therapy in ovarian cancer.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,17(2),325-338.
MLA Zheng, H.,et al."Hormonal therapy in ovarian cancer".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 17.2(2007):325-338.
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