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学科主题临床医学
Investigation on Fourier Transform Infrared Spectrum of Metastatic Lymph Node in Thyroid Cancer
Liu Ya-qi1; Gao Mei-juan1,3; Xu Yi-zhuang2; Sun Qi-gang1; Zhang Xiao-qing1; Xu Zhi1; Zhang Yuan-fu2; Wu Jin-guang2; Zhou Xiaa-si1; Ling Xiao-feng1
关键词Lymph Node Thyroid Cancer Ftir
刊名SPECTROSCOPY AND SPECTRAL ANALYSIS
2009-11-01
DOI10.3964/j.issn.1000-0593(2009)11-2917-05
29期:11页:2917-2921
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Spectroscopy
研究领域[WOS]Spectroscopy
关键词[WOS]SENTINEL ; SPECTROSCOPY ; CARCINOMA ; BIOPSY ; FEASIBILITY
英文摘要

The aim of the study is to explore the possibility of detecting metastatic lymph nodes by FTIR spectra during the surgery of thyroid cancer. The FTIR spectra of 20 metastatic lymph nodes and 69 non-metastatic ones were collected via an ATR (attenuated total reflectance) probe. For each spectrum, 28 variables of 13 bands including peak positions and relative intensities were measured. The variables of metastatic lymph node were compared to those of non-metastatic ones using standard statistic methods. The results indicated that the FTIR spectra of metastatic lymph nodes were significantly different from non-metastatic ones in the bands related to protein, lipid, nucleic acid and carbohydrate. ( 1) Variations of bands related to protein: The relative intensity ratios Of I(3 280)/I(1 460), I(1 640)/I(1 460) and I(1 546)/I(1 460) increased significantly (P<0.05); (2) Variations of bands related to lipid: The relative intensity ratios of I(1 743)/I(1 460) decreased significantly (P<0.05). On the contrary, I(1 400)/I(1 460) increased significantly (P<0.05); (3) The peak positions of 1 165 and 1 120 cm(-1) which were all assigned to carbohydrate shifted toward higher wave number (P<0.05). The relative intensity ratio of I(1 165)/I(1 460) decreased significantly (P<0.05); (4) The peak positions of 1 085 cm(-1) related to nucleic acid shifted to the lower wave number (P<0.05); (5) Other undetermined bands: The relative intensity ratios of I(1 303)/I(1 460) and I(1 303)/I(1 240) increased significantly (P<0.05). FTIR spectroscopy could be a reliable and practicable method for metastatic lymph nodes diagnosis in the operation of thyroid cancer. It could be applied in detecting metastatic lymph nodes which can not be determined by palpation in surgery.

语种中文
WOS记录号WOS:000271875400010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56618
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Beijing Univ Technol, Sch Hosp, Beijing 100124, Peoples R China
推荐引用方式
GB/T 7714
Liu Ya-qi,Gao Mei-juan,Xu Yi-zhuang,et al. Investigation on Fourier Transform Infrared Spectrum of Metastatic Lymph Node in Thyroid Cancer[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2009,29(11):2917-2921.
APA Liu Ya-qi.,Gao Mei-juan.,Xu Yi-zhuang.,Sun Qi-gang.,Zhang Xiao-qing.,...&Ling Xiao-feng.(2009).Investigation on Fourier Transform Infrared Spectrum of Metastatic Lymph Node in Thyroid Cancer.SPECTROSCOPY AND SPECTRAL ANALYSIS,29(11),2917-2921.
MLA Liu Ya-qi,et al."Investigation on Fourier Transform Infrared Spectrum of Metastatic Lymph Node in Thyroid Cancer".SPECTROSCOPY AND SPECTRAL ANALYSIS 29.11(2009):2917-2921.
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