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学科主题: 临床医学
题名:
Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese
作者: Cheng, Wenrong; Zhou, Xujie; Zhu, Li; Shi, Sufang; Lv, Jicheng; Liu, Lijun; Zhang, Hong1
关键词: IgA nephropathy ; MYH9 ; polymorphism
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2011-08-01
DOI: 10.1093/ndt/gfq768
卷: 26, 期:8, 页:2544-U1506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
英文摘要:

Background. IgA nephropathy (IgAN) is the leading cause of end-stage renal disease (ESRD) in China considering different compositions of ESRD causes in different ethnicities. A recent genome-wide association study (GWAS) indicated that the MYH9 gene was significantly associated with non-diabetic ESRD in African-Americans and also influenced kidney function in Europeans. Thus, in the present study, we aim to clarify whether MYH9 confers a shared mechanism among different causes of ESRD and to seek possible further insight into our understanding of IgAN by applying GWAS data from ESRD to IgAN.

Methods. One thousand one hundred and sixteen Chinese, including 527 patients with renal biopsy-proven IgAN and 589 healthy controls, were enrolled in the present study. Four single neucleotide polymorphisms (SNPs) (rs3752462, rs4821480, rs11089788 and rs2413396) reported to be associated with ESRD with the most significance were genotyped by TaqMan assay or a restriction fragment length polymorphism assay for a further case-control study.

Results. None of the four SNPs was associated with the susceptibility to IgAN or clinical and pathological characters at the time of renal biopsy. However, estimated glomerular filtration rate decline rate was associated with rs11089788 in the dominant model (P = 0.021). Cox regression showed that rs11089788 (hazard ratio, 3.95; 95% confidence interval, 1.23-12.63; P = 2.1 x 10(-2)) was an independent predictive factor for renal survival.

Conclusions. Based on a large Chinese IgAN cohort, we found an association between rs11089788 and prognosis of IgAN, adding to the mounting evidence of MYH9 as an important gene in IgAN to ESRD.

语种: 英语
所属项目编号: 30825021 ; 200802052
项目资助者: National Natural Science Foundation of China ; Foundation of Ministry of Health of China
WOS记录号: WOS:000293336500021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56623
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Div Renal, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China

Recommended Citation:
Cheng, Wenrong,Zhou, Xujie,Zhu, Li,et al. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(8):2544-U1506.
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