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Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese
Cheng, Wenrong; Zhou, Xujie; Zhu, Li; Shi, Sufang; Lv, Jicheng; Liu, Lijun; Zhang, Hong1
关键词Iga Nephropathy Myh9 Polymorphism
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2011-08-01
DOI10.1093/ndt/gfq768
26期:8页:2544-U1506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
英文摘要

Background. IgA nephropathy (IgAN) is the leading cause of end-stage renal disease (ESRD) in China considering different compositions of ESRD causes in different ethnicities. A recent genome-wide association study (GWAS) indicated that the MYH9 gene was significantly associated with non-diabetic ESRD in African-Americans and also influenced kidney function in Europeans. Thus, in the present study, we aim to clarify whether MYH9 confers a shared mechanism among different causes of ESRD and to seek possible further insight into our understanding of IgAN by applying GWAS data from ESRD to IgAN.

Methods. One thousand one hundred and sixteen Chinese, including 527 patients with renal biopsy-proven IgAN and 589 healthy controls, were enrolled in the present study. Four single neucleotide polymorphisms (SNPs) (rs3752462, rs4821480, rs11089788 and rs2413396) reported to be associated with ESRD with the most significance were genotyped by TaqMan assay or a restriction fragment length polymorphism assay for a further case-control study.

Results. None of the four SNPs was associated with the susceptibility to IgAN or clinical and pathological characters at the time of renal biopsy. However, estimated glomerular filtration rate decline rate was associated with rs11089788 in the dominant model (P = 0.021). Cox regression showed that rs11089788 (hazard ratio, 3.95; 95% confidence interval, 1.23-12.63; P = 2.1 x 10(-2)) was an independent predictive factor for renal survival.

Conclusions. Based on a large Chinese IgAN cohort, we found an association between rs11089788 and prognosis of IgAN, adding to the mounting evidence of MYH9 as an important gene in IgAN to ESRD.

语种英语
WOS记录号WOS:000293336500021
项目编号30825021 ; 200802052
资助机构National Natural Science Foundation of China ; Foundation of Ministry of Health of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56623
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Div Renal, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Cheng, Wenrong,Zhou, Xujie,Zhu, Li,et al. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(8):2544-U1506.
APA Cheng, Wenrong.,Zhou, Xujie.,Zhu, Li.,Shi, Sufang.,Lv, Jicheng.,...&Zhang, Hong.(2011).Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese.NEPHROLOGY DIALYSIS TRANSPLANTATION,26(8),2544-U1506.
MLA Cheng, Wenrong,et al."Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese".NEPHROLOGY DIALYSIS TRANSPLANTATION 26.8(2011):2544-U1506.
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