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学科主题: 基础医学
题名:
Distribution and antimicrobial resistance of enteric pathogens in Chinese paediatric diarrhoea: a multicentre retrospective study, 2008-2013
作者: Zhang, H.1,2; Pan, F.1,2; Zhao, X.2,3; Wang, G.2,4; Tu, Y.2,4; Fu, S.2,5; Wang, J.2,6; Pan, J.2,7; Song, J.2,7; Wang, W.2,8; Jin, Z.2,8; Xu, H.2,9; Ren, Y.2,9; Li, Y.10; Zhong, N.1,2,3,9,11
关键词: Antibiotic resistance ; bacteriology ; diarrhoea ; Salmonella ; Shigella
刊名: EPIDEMIOLOGY AND INFECTION
发表日期: 2015-09-01
DOI: 10.1017/S0950268814003756
卷: 143, 期:12, 页:2512-2519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health ; Infectious Diseases
研究领域[WOS]: Public, Environmental & Occupational Health ; Infectious Diseases
关键词[WOS]: NONTYPHOIDAL SALMONELLA ; ANTIBIOTIC-RESISTANCE ; CHILDHOOD DIARRHEA ; ASIAN COUNTRIES ; YOUNG-CHILDREN ; UNITED-STATES ; SHIGELLA ; PREVALENCE ; SUSCEPTIBILITY ; INFECTIONS
英文摘要:

The enteric pathogens causing diarrhoea impair children′s health severely. This study retrospectively analysed 1577 pathogens isolated from inpatients and outpatients in six hospitals located in Northern (Inner Mongolia), Northeastern (Hebei), Eastern (Shanghai and Jiangsu), Southern (Hainan) and Central (Hubei) China between 2008 and 2013. Of the 1577 enteric pathogens, Salmonella presented with the highest frequency (36 center dot 0%), followed by diarrhoeagenic Escherichia coli (23 center dot 7%), Staphylococcus aureus (15 center dot 0%), Shigella (13 center dot 1%), and Aeromonas (4 center dot 6%). The predominant pathogens varied in different regions of China, with Salmonella most prevalent in Shanghai and Hainan, diarrhoeagenic E. coli most prevalent in Inner Mongolia, Jiangsu and Hubei, and Shigella most prevalent in Hebei. Enteric pathogens were more frequently isolated in males (56 center dot 9%) than in females (43 center dot 1%). The highest proportion of all enteric pathogens was found in infants (67 center dot 6%) with a peak in summer and autumn (68 center dot 5%). Antimicrobial susceptibility assay demonstrated that Shigella was more resistant to ampicillin, ceftriaxone and sulfamethoxazole than Salmonella. Of the top two serotypes in Salmonella, Typhimurium was more resistant to ciprofloxacin, sulfamethoxazole and chloramphenicol than Enteritidis (P < 0 center dot 001). Meanwhile, the resistance rates of Shigella flexneri against ampicillin/sulbactam, ciprofloxacin, and chloramphenicol were significantly higher than those of Shigella sonnei (P < 0 center dot 001). Multidrug resistance was apparent in 58 center dot 2% of Shigella and 45 center dot 9% of Salmonella, and this phenomenon was more pronounced in S. flexneri.

语种: 英语
所属项目编号: 20124026
项目资助者: Shanghai Municipal Commission of Health and Family Planning ; March of Dimes Global Network for Maternal and Infant Health
WOS记录号: WOS:000358844800005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56624
Appears in Collections:基础医学院_北京大学医学遗传中心_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Clin Lab, Shanghai 200030, Peoples R China
2.China Alliance Translat Med Maternal & Childrens, Beijing, Peoples R China
3.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
4.Inner Mongolia Maternal & Childrens Hosp, Hohhot, Inner Mongolia, Peoples R China
5.Hainan Ctr Dis Control, Haikou, Hainan, Peoples R China
6.Hainan Prov Maternal & Childrens Hosp, Haikou, Hainan, Peoples R China
7.Lianyungang Maternal & Childrens Hosp, Lianyungang, Jiangsu, Peoples R China
8.Hubei Prov Maternal & Childrens Hosp, Wuhan, Hubei, Peoples R China
9.Jiujiang Maternal & Childrens Hosp, Jiujiang, Jiangxi, Peoples R China
10.Shijiazhuang Maternal & Obstetr Hosp, Shijiazhuang, Hubei, Peoples R China
11.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA

Recommended Citation:
Zhang, H.,Pan, F.,Zhao, X.,et al. Distribution and antimicrobial resistance of enteric pathogens in Chinese paediatric diarrhoea: a multicentre retrospective study, 2008-2013[J]. EPIDEMIOLOGY AND INFECTION,2015,143(12):2512-2519.
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