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学科主题: 临床医学
题名:
F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation
作者: Li, Dongnian1; Xie, Ping2; Zhao, Fei3; Shu, Jingyi2; Li, Li1; Zhan, Yutao1; Zhang, Lingqiang2
关键词: Protein ubiquitination ; Proteasomal degradation ; Ubiquitin ligase ; Fbxo3 ; Smurf1
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2015-03-20
DOI: 10.1016/j.bbrc.2015.02.089
卷: 458, 期:4, 页:941-945
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: BREAST-CANCER ; CELL POLARITY ; INFLAMMATION ; PATHWAY
英文摘要:

It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and targets Smurf1 for poly-ubiquitination and proteasomal degradation. Different from Fbx115, Fbxo3 targets all the Nedd4 family members for their degradation, indicating that Fbxo3 plays an important role in controlling the stability of Nedd4. Taken together, we show that Smurfl is an endogenous substrate of Fbxo3. Our study gains further insight into the novel role of Fbxo3 in BMP signaling. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2015CB910401 ; 31470035 ; 81041017
项目资助者: Chinese National Basic Research Programs ; Chinese National Natural Science Foundation
WOS记录号: WOS:000352117400034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56629
Appears in Collections:北京大学首钢医院_超声科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
2.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China
3.Peking Univ, Shougang Hosp, Dept Ultrasound, Beijing 100144, Peoples R China

Recommended Citation:
Li, Dongnian,Xie, Ping,Zhao, Fei,et al. F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,458(4):941-945.
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