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F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation
Li, Dongnian1; Xie, Ping2; Zhao, Fei3; Shu, Jingyi2; Li, Li1; Zhan, Yutao1; Zhang, Lingqiang2
关键词Protein Ubiquitination Proteasomal Degradation Ubiquitin Ligase Fbxo3 Smurf1
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-03-20
DOI10.1016/j.bbrc.2015.02.089
458期:4页:941-945
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]BREAST-CANCER ; CELL POLARITY ; INFLAMMATION ; PATHWAY
英文摘要

It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and targets Smurf1 for poly-ubiquitination and proteasomal degradation. Different from Fbx115, Fbxo3 targets all the Nedd4 family members for their degradation, indicating that Fbxo3 plays an important role in controlling the stability of Nedd4. Taken together, we show that Smurfl is an endogenous substrate of Fbxo3. Our study gains further insight into the novel role of Fbxo3 in BMP signaling. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000352117400034
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56629
专题北京大学首钢医院_超声科
北京大学第三临床医学院_放射科
作者单位1.Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
2.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China
3.Peking Univ, Shougang Hosp, Dept Ultrasound, Beijing 100144, Peoples R China
推荐引用方式
GB/T 7714
Li, Dongnian,Xie, Ping,Zhao, Fei,et al. F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,458(4):941-945.
APA Li, Dongnian.,Xie, Ping.,Zhao, Fei.,Shu, Jingyi.,Li, Li.,...&Zhang, Lingqiang.(2015).F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,458(4),941-945.
MLA Li, Dongnian,et al."F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458.4(2015):941-945.
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