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学科主题: 临床医学
题名:
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
作者: Munoz-Price, L. Silvia1,2,3; Poirel, Laurent4,5; Bonomo, Robert A.6,7,8; Schwaber, Mitchell J.9; Daikos, George L.10; Cormican, Martin11; Cornaglia, Giuseppe12; Garau, Javier13; Gniadkowski, Marek14; Hayden, Mary K.15,16; Kumarasamy, Karthikeyan17; Livermore, David M.18,19; Maya, Juan J.20; Nordmann, Patrice4,5; Patel, Jean B.21; Paterson, David L.22; Pitout, Johann23,24; Villegas, Maria Virginia20; Wang, Hui25; Woodford, Neil19; Quinn, John P.26
刊名: LANCET INFECTIOUS DISEASES
发表日期: 2013-09-01
DOI: 10.1016/S1473-3099(13)70190-7
卷: 13, 期:9, 页:785-796
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: HYDROLYZING BETA-LACTAMASE ; KPC-PRODUCING ENTEROBACTERIACEAE ; GRAM-NEGATIVE BACILLI ; ACUTE-CARE FACILITIES ; NEW-YORK-CITY ; ESCHERICHIA-COLI ; PSEUDOMONAS-AERUGINOSA ; RESISTANT ENTEROBACTERIACEAE ; K.-PNEUMONIAE ; UNITED-STATES
英文摘要:

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile beta-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.

语种: 英语
项目资助者: Sage and Steris ; Merck ; grant Narodowy Program Ochrony Antybiotykow (NPOA) from the Polish Ministry of Health ; grant SPUB MIKROBANK from the Polish Ministry of Science and Higher Education ; Pfizer ; Novartis ; AstraZeneca ; Astellas ; Merck Sharp Dohme ; Pfizer SA ; Janssen-Cilag SA ; Merck Colombia ; AstraZeneca Colombia SA ; bioMerieux Colombia SAS ; Colciencias
WOS记录号: WOS:000323465900024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56633
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Miami, Miller Sch Med, Dept Med, Dept Publ Hlth Sci, Miami, FL 33136 USA
2.Univ Miami, Miller Sch Med, Dept Anesthesiol, Miami, FL 33136 USA
3.Jackson Mem Hosp, Dept Infect Control, Miami, FL 33136 USA
4.Hop Bicetre, AP HP, Serv Bacteriol Virol, INSERM Emerging Resistance Antibiot U914,Fac Med, K Bicetre, France
5.Univ Paris Sud, K Bicetre, France
6.Louis Stokes Cleveland Dept Vet Affairs, Res Serv, Cleveland, OH USA
7.Case Western Reserve Univ, Dept Med Pharmacol, Dept Mol Biol, Cleveland, OH 44106 USA
8.Case Western Reserve Univ, Dept Microbiol, Cleveland, OH 44106 USA
9.Israel Minist Hlth, Natl Ctr Infect Control, Tel Aviv, Israel
10.Univ Athens, Sch Med, Dept Propaedeut Med, GR-11527 Athens, Greece
11.Natl Univ Ireland Galway, Sch Med, Antimicrobial Resistance & Microbial Ecol ARME Gr, Galway, Ireland
12.Univ Verona, Dept Pathol & Diagnost, I-37100 Verona, Italy
13.Univ Barcelona, Infect Dis Unit, Hosp Univ Mutua Terrassa, Barcelona, Spain
14.Natl Med Inst, Dept Mol Microbiol, Warsaw, Poland
15.Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA
16.Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA
17.Univ Madras, Dept Microbiol, Dr ALM PG IBMS, Madras, Tamil Nadu, India
18.Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
19.Publ Hlth England, Antimicrobial Resistance & Healthcare Assoc Infec, London, England
20.Int Ctr Med Res andTraining CIDEIM, Cali, Colombia
21.Ctr Dis Control & Prevent, Atlanta, GA USA
22.Univ Queensland, Clin Res Ctr, Royal Brisbane & Womens Hosp, Herston, Qld, Australia
23.Calgary Lab Serv, Div Microbiol, Calgary, AB, Canada
24.Univ Calgary, Dept Pathol & Lab Med, Calgary, AB, Canada
25.AstraZeneca, Waltham, MA USA
26.Peking Univ Peoples Hosp, Dept Clin Lab, Beijing, Peoples R China

Recommended Citation:
Munoz-Price, L. Silvia,Poirel, Laurent,Bonomo, Robert A.,et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases[J]. LANCET INFECTIOUS DISEASES,2013,13(9):785-796.
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