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学科主题临床医学
Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo
Fan, Cungang; Wang, Dongliang; Zhang, Qingjun; Zhou, Jingru
关键词Neural Regeneration Umbilical Cord Mesenchymal Stem Cell Glioma Migration Cell-based Therapy Grants-supported Paper Neuroregeneration
刊名NEURAL REGENERATION RESEARCH
2013-08-01
DOI10.3969/j.issn.1673-5374.2013.22.009
8期:22页:2093-2102
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]MARROW STROMAL CELLS ; HIGH-GRADE GLIOMAS ; GLIOBLASTOMA-MULTIFORME ; GENE-THERAPY ; MALIGNANT GLIOMAS ; BRAIN ; DIFFERENTIATION ; RADIOTHERAPY ; BEVACIZUMAB ; TROPISM
英文摘要

High-grade glioma is the most common malignant primary brain tumor in adults. The poor prognosis of glioma, combined with a resistance to currently available treatments, necessitates the development of more effective tumor-selective therapies. Stem cell-based therapies are emerging as novel cell-based delivery vehicle for therapeutic agents. In the present study, we successfully isolated human umbilical cord mesenchymal stem cells by explant culture. The human umbilical cord mesenchymal stem cells were adherent to plastic surfaces, expressed specific surface phenotypes of mesenchymal stem cells as demonstrated by flow cytometry, and possessed multi-differentiation potentials in permissive induction media in vitro. Furthermore, human umbilical cord mesenchymal stem cells demonstrated excellent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. The excellent glioma-specific targeting ability and extensive intratumoral distribution of human umbilical cord mesenchymal stem cells indicate that they may serve as a novel cellular vehicle for delivering therapeutic molecules in glioma therapy.

语种英语
所属项目编号81001009
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000323990900009
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56636
Collection北京大学第二临床医学院_神经外科
作者单位Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Fan, Cungang,Wang, Dongliang,Zhang, Qingjun,et al. Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo[J]. NEURAL REGENERATION RESEARCH,2013,8(22):2093-2102.
APA Fan, Cungang,Wang, Dongliang,Zhang, Qingjun,&Zhou, Jingru.(2013).Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo.NEURAL REGENERATION RESEARCH,8(22),2093-2102.
MLA Fan, Cungang,et al."Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo".NEURAL REGENERATION RESEARCH 8.22(2013):2093-2102.
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