IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Progress in gene transfer by germ cells in mammals
Niu, Yidong1; Liang, Shulong2
关键词Germ Cell Sperm-mediated Gene Transfer Testis-mediated Gene Transfer Ovary-mediated Gene Transfer
刊名JOURNAL OF GENETICS AND GENOMICS
2008-12-01
35期:12页:701-714
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]INTRACYTOPLASMIC SPERM INJECTION ; LINE STEM-CELLS ; XENOPUS-LAEVIS OOCYTES ; MEDIATED MOUSE TRANSGENESIS ; IN-VIVO ELECTROPORATION ; FOREIGN DNA ; EXOGENOUS DNA ; HOMOLOGOUS RECOMBINATION ; REVERSE-TRANSCRIPTASE ; PLASMID DNA
英文摘要

Use of germ cells as vectors for transgenesis in mammals has been well developed and offers exciting prospects for experimental and applied biology, agricultural and medical sciences. Such approach is referred to as either male germ cell mediated gene transfer (MGCMGT) or female germ cell mediated gene transfer (FGCMGT) technique. Sperm-mediated gene transfer (SMGT), including its alternative method, testis-mediated gene transfer (TMGT), becomes an established and reliable method for transgenesis. They have been extensively used for producing transgenic animals. The newly developed approach of FGCMGT, ovary-mediated gene transfer (OMGT) is also a novel and useful tool for efficient transgenesis. This review highlights an overview of the recent progress in germ cell mediated gene transfer techniques, methods developed and mechanisms of nucleic acid uptake by germ cells.

语种英语
WOS记录号WOS:000263427800001
项目编号RDB2007-03
资助机构Peking University People&prime ; s Hospital Research and Development Foundation
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56641
专题北京大学第二临床医学院
北京大学第二临床医学院_动物实验室
作者单位1.Peking Univ, Peoples Hosp, Lab Anim Ctr, Beijing 100044, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Niu, Yidong,Liang, Shulong. Progress in gene transfer by germ cells in mammals[J]. JOURNAL OF GENETICS AND GENOMICS,2008,35(12):701-714.
APA Niu, Yidong,&Liang, Shulong.(2008).Progress in gene transfer by germ cells in mammals.JOURNAL OF GENETICS AND GENOMICS,35(12),701-714.
MLA Niu, Yidong,et al."Progress in gene transfer by germ cells in mammals".JOURNAL OF GENETICS AND GENOMICS 35.12(2008):701-714.
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