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学科主题: 基础医学
题名:
The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray
作者: He, Huiying2; Zhou, Grace X.3; Zhou, Ming; Chen, Longwen1
关键词: Clear cell carcinoma of the female genital tract ; Clear cell renal cell carcinoma ; Translocation-associated renal cell carcinoma ; Immunohistochemistry
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
发表日期: 2011-09-01
DOI: 10.1097/PGP.0b013e318214dd4f
卷: 30, 期:5, 页:425-430
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Pathology
研究领域[WOS]: Obstetrics & Gynecology ; Pathology
关键词[WOS]: CARBONIC-ANHYDRASE-IX ; EPITHELIAL NEOPLASMS ; GYNECOLOGIC TRACT ; CD10 EXPRESSION ; OVARIAN ; IMMUNOREACTIVITY ; ADENOCARCINOMA ; METASTASIS ; TUMORS ; PROGNOSIS
英文摘要:

Clear cell carcinoma of the female genital tract (CCCa) shares many histologic features with clear cell renal cell carcinoma (CCRCC) and translocation-associated renal cell carcinoma (TA-RCC), the latter in particular. When CCRCC or TA-RCC metastasizes to the female genital tract, or when patients have a history of both CCCa- and RCC-developed metastatic lesions, it is critical to distinguish the 3 lesions. Such a distinction is not always possible based on the morphology alone and often requires immunostains. We therefore investigated the utility of a panel of routinely used immunohistochemical markers including cytokeratin (CK) 7 and 20, CD10, alpha-methylacyl-CoA racemase, carbonic anhydrase IX (CA IX), TFE3, and WT-1 in the distinction of the 3 lesions on a tissue microarray of 12 CCCa, 5 TA-RCC, and 23 CCRCC cases. CK7 was positive in all CCCa cases, but only in 20% of TA-RCCs and 4.3% of CCRCCs. In contrast, CD10 was positive in all TA-RCCs and 91.3% of CCRCCs, but in only 7.5% of CCCa cases. TFE3 was positive in all TA-RCCs, but negative in all CCCa and CCRCC cases. CA IX was positive in 87% of CCRCCs, but in only 20% of TA-RCCs, and was negative in all CCCa cases. CK20, alpha-methylacyl-CoA racemase, and WT-1 were not contributory to the distinction. Although morphologically similar, CCCa can be reliably distinguished from TA-RCC and CCRCC. CCCa is mostly CK7(+)/CD10(-)/CA IX-/TFE3(-), TA-RCC is usually CK7(-)/CD10(+)/CA IX-/TFE3(+), whereas CCRCC is mostly CK7(-)/CD10(+)/CA IX+/TFE3(-). To the best of our knowledge, this was the first study to directly compare the immunophenotypes of these 3 lesions.

语种: 英语
WOS记录号: WOS:000293689000002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56647
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Duke Univ, Dept Publ Policy, Durham, NC USA
2.Cleveland Clin, Pathol & Lab Med Inst, Dept Anat Pathol, Cleveland, OH 44195 USA
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
He, Huiying,Zhou, Grace X.,Zhou, Ming,et al. The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2011,30(5):425-430.
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