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学科主题基础医学
The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray
He, Huiying2; Zhou, Grace X.3; Zhou, Ming; Chen, Longwen1
关键词Clear cell carcinoma of the female genital tract Clear cell renal cell carcinoma Translocation-associated renal cell carcinoma Immunohistochemistry
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
2011-09-01
DOI10.1097/PGP.0b013e318214dd4f
30期:5页:425-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Pathology
研究领域[WOS]Obstetrics & Gynecology ; Pathology
关键词[WOS]CARBONIC-ANHYDRASE-IX ; EPITHELIAL NEOPLASMS ; GYNECOLOGIC TRACT ; CD10 EXPRESSION ; OVARIAN ; IMMUNOREACTIVITY ; ADENOCARCINOMA ; METASTASIS ; TUMORS ; PROGNOSIS
英文摘要

Clear cell carcinoma of the female genital tract (CCCa) shares many histologic features with clear cell renal cell carcinoma (CCRCC) and translocation-associated renal cell carcinoma (TA-RCC), the latter in particular. When CCRCC or TA-RCC metastasizes to the female genital tract, or when patients have a history of both CCCa- and RCC-developed metastatic lesions, it is critical to distinguish the 3 lesions. Such a distinction is not always possible based on the morphology alone and often requires immunostains. We therefore investigated the utility of a panel of routinely used immunohistochemical markers including cytokeratin (CK) 7 and 20, CD10, alpha-methylacyl-CoA racemase, carbonic anhydrase IX (CA IX), TFE3, and WT-1 in the distinction of the 3 lesions on a tissue microarray of 12 CCCa, 5 TA-RCC, and 23 CCRCC cases. CK7 was positive in all CCCa cases, but only in 20% of TA-RCCs and 4.3% of CCRCCs. In contrast, CD10 was positive in all TA-RCCs and 91.3% of CCRCCs, but in only 7.5% of CCCa cases. TFE3 was positive in all TA-RCCs, but negative in all CCCa and CCRCC cases. CA IX was positive in 87% of CCRCCs, but in only 20% of TA-RCCs, and was negative in all CCCa cases. CK20, alpha-methylacyl-CoA racemase, and WT-1 were not contributory to the distinction. Although morphologically similar, CCCa can be reliably distinguished from TA-RCC and CCRCC. CCCa is mostly CK7(+)/CD10(-)/CA IX-/TFE3(-), TA-RCC is usually CK7(-)/CD10(+)/CA IX-/TFE3(+), whereas CCRCC is mostly CK7(-)/CD10(+)/CA IX+/TFE3(-). To the best of our knowledge, this was the first study to directly compare the immunophenotypes of these 3 lesions.

语种英语
WOS记录号WOS:000293689000002
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56647
专题北京大学基础医学院_病理学系
作者单位1.Duke Univ, Dept Publ Policy, Durham, NC USA
2.Cleveland Clin, Pathol & Lab Med Inst, Dept Anat Pathol, Cleveland, OH 44195 USA
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
He, Huiying,Zhou, Grace X.,Zhou, Ming,et al. The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2011,30(5):425-430.
APA He, Huiying,Zhou, Grace X.,Zhou, Ming,&Chen, Longwen.(2011).The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray.INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,30(5),425-430.
MLA He, Huiying,et al."The Distinction of Clear Cell Carcinoma of the Female Genital Tract, Clear Cell Renal Cell Carcinoma, and Translocation-Associated Renal Cell Carcinoma: An Immunohistochemical Study Using Tissue Microarray".INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 30.5(2011):425-430.
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