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学科主题: 临床医学
题名:
Mechanisms underlying arrhythmogenesis in long QT syndrome
作者: Lankipalli, RS; Zhu, TG; Guo, DL; Yan, GX
关键词: long QT syndrome ; arrhythmogenesis ; Torsades de pointes
刊名: JOURNAL OF ELECTROCARDIOLOGY
发表日期: 2005-10-01
DOI: 10.1016/j.jelectrocard.2005.06.008
卷: suppl.S, 期:4, 页:69-73
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: TORSADE-DE-POINTES ; LEFT-VENTRICULAR WALL ; TRANSMURAL DISPERSION ; CELLULAR BASIS ; M-CELLS ; T-WAVE ; EARLY AFTERDEPOLARIZATION ; REPOLARIZATION ; INTERVAL ; ARRHYTHMIAS
英文摘要:

Long QT syndrome is a disease of delayed ventricular repolarization. It manifests clinically as recurrent syncope and sudden cardiac death caused by an atypical form of polymorphic ventricular tachycardia known as torsades de pointes (TdP). Evidence obtained from the studies using the rabbit left and right ventricular wedge preparations indicates that the development of UP is relying not only on the genesis of air R-on-T trigger, but also on the formation of a functional reentrant substrate. When ventricular endocardial or subendocardial repolarization is prolonged either because of gene mutations or by drugs that reduce the net repolarization current, cell membrane potential fluctuates during phase 2 of the action potential phase 2 because of reactivation of L-type calcium Current, that is, the appearance of phase 2 early afterdepolarization (EAD). In the rabbit left ventricular wedge, QT prolongation and EAD due to pure I-Kr inhibition are accompanied by a disproportional increase in transmural dispersion of repolarization (TDR). Early afterdepolarization in endocardium or subendocardium is able to produce new action potentials in cells with a relatively short action potential duration (eg, ventricular epicardium) probably via an electrotonic effect Mien TDR is large enough. This, in turn, results in an R-on-T extrasystole that is capable of initiating UP. Enhanced TDR is essential not only for the genesis of the first initiating beat of TdP by facilitating the propagation of EAD, but also for the maintenance of TdP by serving as a functional reentrant substrate. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000233191000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56648
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA
2.Lankenau Inst Med Res, Wynnewood, PA 19096 USA
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Lankipalli, RS,Zhu, TG,Guo, DL,et al. Mechanisms underlying arrhythmogenesis in long QT syndrome[J]. JOURNAL OF ELECTROCARDIOLOGY,2005,suppl.S(4):69-73.
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