IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention
Wang, Xinyu1,2,3,4; Yu, Haiyi1,2,3,4; Li, Zhaoping1,2,3,4; Li, Liuning1,2,3,4; Zhang, Youyi1,2,3,4; Gao, Wei1,2,3,4
刊名MEDIATORS OF INFLAMMATION
2014
DOI10.1155/2014/482763
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; CLINICAL-OUTCOMES ; HEART-FAILURE ; FRAME COUNT ; TRIAL ; ANGIOPLASTY ; REPERFUSION ; MORTALITY ; MYELOPEROXIDASE ; CYTOKINES
英文摘要

Inflammation plays an important role in plaque development and left ventricular remodeling during acute myocardial infarction (AMI). Clopidogrel may exhibit some anti-inflammatory properties and high loading dose of clopidogrel results in improved clinical outcomes in patients with AMI. 357 patients who received successful primary percutaneous coronary intervention from January 2008 to March 2011 in Peking University Third Hospital were included in this study. Different loading dose of clopidogrel (300 mg, 450 mg, or 600 mg) was given at the discretion of the clinician. Neutrophils reached their peak values on the first day after AMI. Higher levels of peak neutrophil and lower left ventricular ejection fraction (LVEF) were found in patients of low clopidogrel loading dose group (300 mg or 450 mg). After adjusting for the related confounders, a logistic regression model showed that low clopidogrel loading dose remained an independent predictor of low LVEF (LVEF <= 50%) [OR: 1.97, 95% CI: 1.03-3.79, P = 0.04]. Low clopidogrel loading dose was associated with higher peak neutrophil count and poor left ventricular systolic function, suggesting an important role of clopidogrel loading dose in the improvement of left ventricular function and high loading dose may exhibit better anti-inflammatory properties.

语种英语
WOS记录号WOS:000340274700001
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56653
Collection北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Dept Cardiol, Beijing 100083, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
4.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xinyu,Yu, Haiyi,Li, Zhaoping,et al. Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention[J]. MEDIATORS OF INFLAMMATION,2014.
APA Wang, Xinyu,Yu, Haiyi,Li, Zhaoping,Li, Liuning,Zhang, Youyi,&Gao, Wei.(2014).Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention.MEDIATORS OF INFLAMMATION.
MLA Wang, Xinyu,et al."Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention".MEDIATORS OF INFLAMMATION (2014).
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