IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention
Wang, Xinyu1,2,3,4; Yu, Haiyi1,2,3,4; Li, Zhaoping1,2,3,4; Li, Liuning1,2,3,4; Zhang, Youyi1,2,3,4; Gao, Wei1,2,3,4
刊名MEDIATORS OF INFLAMMATION
2014
DOI10.1155/2014/482763
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
资助者Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Projects of International Cooperation and Exchanges NSFC ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Projects of International Cooperation and Exchanges NSFC
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; CLINICAL-OUTCOMES ; HEART-FAILURE ; FRAME COUNT ; TRIAL ; ANGIOPLASTY ; REPERFUSION ; MORTALITY ; MYELOPEROXIDASE ; CYTOKINES
英文摘要

Inflammation plays an important role in plaque development and left ventricular remodeling during acute myocardial infarction (AMI). Clopidogrel may exhibit some anti-inflammatory properties and high loading dose of clopidogrel results in improved clinical outcomes in patients with AMI. 357 patients who received successful primary percutaneous coronary intervention from January 2008 to March 2011 in Peking University Third Hospital were included in this study. Different loading dose of clopidogrel (300 mg, 450 mg, or 600 mg) was given at the discretion of the clinician. Neutrophils reached their peak values on the first day after AMI. Higher levels of peak neutrophil and lower left ventricular ejection fraction (LVEF) were found in patients of low clopidogrel loading dose group (300 mg or 450 mg). After adjusting for the related confounders, a logistic regression model showed that low clopidogrel loading dose remained an independent predictor of low LVEF (LVEF <= 50%) [OR: 1.97, 95% CI: 1.03-3.79, P = 0.04]. Low clopidogrel loading dose was associated with higher peak neutrophil count and poor left ventricular systolic function, suggesting an important role of clopidogrel loading dose in the improvement of left ventricular function and high loading dose may exhibit better anti-inflammatory properties.

语种英语
所属项目编号7144254 ; 81370317 ; 30910103902
资助者Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Projects of International Cooperation and Exchanges NSFC ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Projects of International Cooperation and Exchanges NSFC
WOS记录号WOS:000340274700001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56653
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Dept Cardiol, Beijing 100083, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
4.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xinyu,Yu, Haiyi,Li, Zhaoping,et al. Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention[J]. MEDIATORS OF INFLAMMATION,2014.
APA Wang, Xinyu,Yu, Haiyi,Li, Zhaoping,Li, Liuning,Zhang, Youyi,&Gao, Wei.(2014).Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention.MEDIATORS OF INFLAMMATION.
MLA Wang, Xinyu,et al."Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention".MEDIATORS OF INFLAMMATION (2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Xinyu]的文章
[Yu, Haiyi]的文章
[Li, Zhaoping]的文章
百度学术
百度学术中相似的文章
[Wang, Xinyu]的文章
[Yu, Haiyi]的文章
[Li, Zhaoping]的文章
必应学术
必应学术中相似的文章
[Wang, Xinyu]的文章
[Yu, Haiyi]的文章
[Li, Zhaoping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。