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学科主题临床医学
Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients
Xiong, Gengyan1; Chen, Xiaopeng1; Li, Xuesong1; Fang, Dong1; Zhang, Luxia2,3; Yang, Li2,3; Zhang, Lei1; Yao, Lin1; He, Zhisong1; Zhou, Liqun1
关键词Chinese Population Chronic Kidney Disease Upper Urinary Tract Carcinoma Urothelial Carcinoma
刊名JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
2014-08-01
DOI10.1016/j.jfma.2013.04.001
113期:8页:521-526
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]TRANSITIONAL-CELL CARCINOMA ; BLADDER-CANCER ; NEOADJUVANT CHEMOTHERAPY ; CARDIOVASCULAR-DISEASE ; SERUM CREATININE ; NEPHROURETERECTOMY ; RECURRENCE ; COHORT ; RISK ; CKD
英文摘要

Background/Purpose: There is relatively little literature on prevalence of chronic kidney disease (CKD) prior to surgery in patients with upper urinary tract urothelial carcinoma (UTUC). We evaluated the prevalence and clinical associated factors of baseline CKD in patients with UTUC.

Methods: There were 785 patients with a pathologic diagnosis of UTUC from January 2002 to December 2011 who were analyzed in this study. Estimated glomerular filtration rate (eGFR) was calculated by re-expressed Modification of Diet in Renal Disease (MDRD) formulas for the Chinese population. A multivariate logistic regression was performed to evaluate the odds ratios (ORs) for CKD stage 3 or higher in UTUCs after data differences were tested.

Results: The prevalence of CKD in UTUCs presenting at our hospital was 58.6% and 70.8% in the group age 70 years and older. Older age [per year increased; OR = 1.050; 95% confidence interval (CI): 1.034-1.067], lower tumor stage (T stage; per stage increased; OR = 0.666; 95% CI: 0.544-0.816), higher tumor grade (per grade increased; OR = 1.392; 95% CI: 1.004-1.930) and the main tumor locating in the pelvis (ureter as reference; OR = 0.648; 95% CI: 0.475-0.885) were independently associated with decreased kidney function in the multivariate logistic regression. The use of serum creatinine (Scr) only to evaluate the renal function would ignore a large proportion of patients suffering from CKD stage 3 in UTUCs, especially in those older than 70 years (39.3% vs. 54.1%, p = 0.022).

Conclusion: We demonstrated a high prevalence (58.6%) of CKD in patients with UTUC, particularly in the group older than 70 years (70.8%). Older age, lower T stage, higher tumor grade, and the main tumor locating in pelvis (ureter as reference) were independently associated with CKD in UTUCs. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.

语种英语
WOS记录号WOS:000341062500006
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56655
专题北京大学第一临床医学院_泌尿外科
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Dept Urol, Hosp 1, Inst Urol,Natl Urol Canc Ctr, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Div Nephrol, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Xiong, Gengyan,Chen, Xiaopeng,Li, Xuesong,et al. Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients[J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION,2014,113(8):521-526.
APA Xiong, Gengyan.,Chen, Xiaopeng.,Li, Xuesong.,Fang, Dong.,Zhang, Luxia.,...&Zhou, Liqun.(2014).Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients.JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION,113(8),521-526.
MLA Xiong, Gengyan,et al."Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients".JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 113.8(2014):521-526.
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