IR@PKUHSC  > 北京大学口腔医学院  > 牙周科
学科主题口腔医学
Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption
He, D.1,2; Kou, X.1,2; Luo, Q.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Song, Y.1,2; Cao, H.1,2; Zeng, M.1,2; Gan, Y.3; Zhou, Y.1,2
关键词Phenotype Orthodontics Biomechanical Phenomena Macrophage Activation Bone Remodeling Inflammation
刊名JOURNAL OF DENTAL RESEARCH
2015
DOI10.1177/0022034514553817
94期:1页:129-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]HUMAN PERIODONTAL-LIGAMENT ; TEMPOROMANDIBULAR-JOINT ; OVARIECTOMIZED RATS ; TOOTH MOVEMENT ; ALVEOLAR BONE ; TNF-ALPHA ; MONOCYTES ; CELLS ; ACTIVATION ; HETEROGENEITY
英文摘要

Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-gamma and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-alpha inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio.

语种英语
WOS记录号WOS:000346506200017
项目编号81300897 ; 2013DFB30360
资助机构National Natural Science Foundation of China ; International S&amp ; T cooperation program of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56658
专题北京大学口腔医学院_牙周科
北京大学基础医学院
北京大学第三临床医学院_心血管内科
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
He, D.,Kou, X.,Luo, Q.,et al. Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption[J]. JOURNAL OF DENTAL RESEARCH,2015,94(1):129-139.
APA He, D..,Kou, X..,Luo, Q..,Yang, R..,Liu, D..,...&Zhou, Y..(2015).Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption.JOURNAL OF DENTAL RESEARCH,94(1),129-139.
MLA He, D.,et al."Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption".JOURNAL OF DENTAL RESEARCH 94.1(2015):129-139.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Enhanced M1_M2 Macro(1007KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He, D.]的文章
[Kou, X.]的文章
[Luo, Q.]的文章
百度学术
百度学术中相似的文章
[He, D.]的文章
[Kou, X.]的文章
[Luo, Q.]的文章
必应学术
必应学术中相似的文章
[He, D.]的文章
[Kou, X.]的文章
[Luo, Q.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Enhanced M1_M2 Macrophage Ratio Promotes Orthodontic Root Resorption.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。