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学科主题口腔医学
Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption
He, D.1,2; Kou, X.1,2; Luo, Q.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Song, Y.1,2; Cao, H.1,2; Zeng, M.1,2; Gan, Y.3; Zhou, Y.1,2
关键词Phenotype Orthodontics Biomechanical Phenomena Macrophage Activation Bone Remodeling Inflammation
刊名JOURNAL OF DENTAL RESEARCH
2015
DOI10.1177/0022034514553817
94期:1页:129-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; International S&amp ; T cooperation program of China ; National Natural Science Foundation of China ; International S&amp ; T cooperation program of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]HUMAN PERIODONTAL-LIGAMENT ; TEMPOROMANDIBULAR-JOINT ; OVARIECTOMIZED RATS ; TOOTH MOVEMENT ; ALVEOLAR BONE ; TNF-ALPHA ; MONOCYTES ; CELLS ; ACTIVATION ; HETEROGENEITY
英文摘要

Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-gamma and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-alpha inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio.

语种英语
所属项目编号81300897 ; 2013DFB30360
资助者National Natural Science Foundation of China ; International S&amp ; T cooperation program of China ; National Natural Science Foundation of China ; International S&amp ; T cooperation program of China
WOS记录号WOS:000346506200017
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56658
Collection北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
He, D.,Kou, X.,Luo, Q.,et al. Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption[J]. JOURNAL OF DENTAL RESEARCH,2015,94(1):129-139.
APA He, D..,Kou, X..,Luo, Q..,Yang, R..,Liu, D..,...&Zhou, Y..(2015).Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption.JOURNAL OF DENTAL RESEARCH,94(1),129-139.
MLA He, D.,et al."Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption".JOURNAL OF DENTAL RESEARCH 94.1(2015):129-139.
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