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学科主题: 口腔医学
题名:
Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption
作者: He, D.1,2; Kou, X.1,2; Luo, Q.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Song, Y.1,2; Cao, H.1,2; Zeng, M.1,2; Gan, Y.3; Zhou, Y.1,2
关键词: phenotype ; orthodontics ; biomechanical phenomena ; macrophage activation ; bone remodeling ; inflammation
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015
DOI: 10.1177/0022034514553817
卷: 94, 期:1, 页:129-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: HUMAN PERIODONTAL-LIGAMENT ; TEMPOROMANDIBULAR-JOINT ; OVARIECTOMIZED RATS ; TOOTH MOVEMENT ; ALVEOLAR BONE ; TNF-ALPHA ; MONOCYTES ; CELLS ; ACTIVATION ; HETEROGENEITY
英文摘要:

Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-gamma and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-alpha inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio.

语种: 英语
所属项目编号: 81300897 ; 2013DFB30360
项目资助者: National Natural Science Foundation of China ; International S&amp ; T cooperation program of China
WOS记录号: WOS:000346506200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56658
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
He, D.,Kou, X.,Luo, Q.,et al. Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption[J]. JOURNAL OF DENTAL RESEARCH,2015,94(1):129-139.
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