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学科主题: 公共卫生
题名:
Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population
作者: Chen, Zhen1,2,5; Meng, Huan1,2,5; Xing, Gengmei1,2; Yuan, Hui1,2; Zhao, Feng1,2; Liu, Ru1,2,5; Chang, Xuelin1,2; Gao, Xueyun1,2,5; Wang, Tiancheng4; Jia, Guang3; Ye, Chang1,2; Chai, Zhifang1,2; Zhao, Yuliang1,2,5
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2008-12-01
DOI: 10.1021/es800975u
卷: 42, 期:23, 页:8985-8992
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
关键词[WOS]: PARTICULATE AIR-POLLUTION ; DIESEL EXHAUST PARTICLES ; ULTRAFINE PARTICLES ; MAST-CELLS ; INFLAMMATION ; HEART ; LUNG ; ASSOCIATION ; MORTALITY ; DISEASE
英文摘要:

Epidemiologic studies have revealed that pollution by ambient particulates is associated with respiratory and cardiovascular diseases, particularly in older people. Toxicologic sensitivity of nanoparticles in different ages was investigated for the first time to demonstrate and explain an age-related difference in response to manufactured nanoparticles. Young, adult, and old rats physiologically inhaled air containing aerosol of manufactured SiO(2) nanoparticles (24.1 mg/m(3); 40 min/day) for four weeks. Changes in serum biomarkers, hemorheologic, pulmonary inflammation, heart injury, and pathology in rats of different ages and their corresponding controls were compared. Inhalation of SiO(2) nanoparticles under identical conditions caused pulmonary and cardiovascular alterations in old rats, yet less change in young and adult rats, including pulmonary inflammation, myocardial ischernic damage, atrio-ventricular blockage, and increase in fibrinogen concentration and blood viscosity. Old individuals were more sensitive to nanoparticle exposure than the young and adult rats. The risk of causing pulmonary damages was: old > young > adult. The risk of cardiovascular disorder was observed only in old age. Our results suggest that different ages may require different biomarkers for identifying pulmonary toxicity during inhalation of nanoparticles.

语种: 英语
所属项目编号: 2006CB705601 ; 2009CB930204 ; 10525524 ; 10675141
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号: WOS:000261307200063
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56667
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Chen, Zhen,Meng, Huan,Xing, Gengmei,et al. Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2008,42(23):8985-8992.
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