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Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population
Chen, Zhen1,2,5; Meng, Huan1,2,5; Xing, Gengmei1,2; Yuan, Hui1,2; Zhao, Feng1,2; Liu, Ru1,2,5; Chang, Xuelin1,2; Gao, Xueyun1,2,5; Wang, Tiancheng4; Jia, Guang3; Ye, Chang1,2; Chai, Zhifang1,2; Zhao, Yuliang1,2,5
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
2008-12-01
DOI10.1021/es800975u
42期:23页:8985-8992
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Environmental ; Environmental Sciences
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
关键词[WOS]PARTICULATE AIR-POLLUTION ; DIESEL EXHAUST PARTICLES ; ULTRAFINE PARTICLES ; MAST-CELLS ; INFLAMMATION ; HEART ; LUNG ; ASSOCIATION ; MORTALITY ; DISEASE
英文摘要

Epidemiologic studies have revealed that pollution by ambient particulates is associated with respiratory and cardiovascular diseases, particularly in older people. Toxicologic sensitivity of nanoparticles in different ages was investigated for the first time to demonstrate and explain an age-related difference in response to manufactured nanoparticles. Young, adult, and old rats physiologically inhaled air containing aerosol of manufactured SiO(2) nanoparticles (24.1 mg/m(3); 40 min/day) for four weeks. Changes in serum biomarkers, hemorheologic, pulmonary inflammation, heart injury, and pathology in rats of different ages and their corresponding controls were compared. Inhalation of SiO(2) nanoparticles under identical conditions caused pulmonary and cardiovascular alterations in old rats, yet less change in young and adult rats, including pulmonary inflammation, myocardial ischernic damage, atrio-ventricular blockage, and increase in fibrinogen concentration and blood viscosity. Old individuals were more sensitive to nanoparticle exposure than the young and adult rats. The risk of causing pulmonary damages was: old > young > adult. The risk of cardiovascular disorder was observed only in old age. Our results suggest that different ages may require different biomarkers for identifying pulmonary toxicity during inhalation of nanoparticles.

语种英语
所属项目编号2006CB705601 ; 2009CB930204 ; 10525524 ; 10675141
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号WOS:000261307200063
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56667
专题北京大学公共卫生学院
作者单位1.Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Chen, Zhen,Meng, Huan,Xing, Gengmei,et al. Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2008,42(23):8985-8992.
APA Chen, Zhen.,Meng, Huan.,Xing, Gengmei.,Yuan, Hui.,Zhao, Feng.,...&Zhao, Yuliang.(2008).Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population.ENVIRONMENTAL SCIENCE & TECHNOLOGY,42(23),8985-8992.
MLA Chen, Zhen,et al."Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population".ENVIRONMENTAL SCIENCE & TECHNOLOGY 42.23(2008):8985-8992.
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