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Monozygotic co-twin analyses of body composition measurements and serum lipids
Wang, Binyan2,3; Necheles, Jonathan1,2; Ouyang, Fengxiu2,3; Ma, Wei4; Li, Zhiping5; Liu, Xue5; Yang, Jianhua5; Xing, Houxun5; Xu, Xiping6; Wang, Xiaobin2,3
关键词Body Fat Body Mass Index Lean Body Mass Monozygotic Twins Obesity Chinese Serum Lipids
刊名PREVENTIVE MEDICINE
2007-11-01
DOI10.1016/j.ypmed.2007.07.014
45期:5页:358-365
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health ; Medicine, General & Internal
研究领域[WOS]Public, Environmental & Occupational Health ; General & Internal Medicine
关键词[WOS]CARDIOVASCULAR RISK-FACTORS ; BIOELECTRICAL-IMPEDANCE ANALYSIS ; X-RAY ABSORPTIOMETRY ; MASS INDEX ; BLOOD-PRESSURE ; HUMAN OBESITY ; PIMA-INDIANS ; YOUNG-ADULTS ; CHINA ; FAT
英文摘要

Objective. To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis.

Methods. Adiposity measures collected 1998-2000 on 987 MZ female 20-60 year old twin pairs (n=1974) included BMI, waist circumference (WC), waist/hip ratio (WHR), LBM, trunk fat (TF), %TF, total BF, and % total BF (measured by DEXA). Serum lipids included total cholesterol (TC), triglycerides (TG), LDL, and HDL. Co-twin analyses and conventional regression analyses were used to assess the association between individual adiposity and LBM measures, and serum lipids.

Results. In this lean population with a mean BMI 21.8 (2.8), we observed considerable variability in adiposity measures and serum lipids. A positive linear association between all adiposity measures with LDL, TC, and TG, and a negative linear association with HDL was observed. A 1-unit z-score increase of adiposity measures, reflecting fat distribution, was associated with increases in (mmol/L) TC (0.063 to 0.164), LDL (0.064 to 0.131), TG (0.049 to 0.164), and a decrease in HDL (0.021 to 0.038) while controlling for matched factors within twin pairs (i.e., age and unmeasured confounders). However, similar associations were not observed for LBM.

Conclusion. It is the BF (not LBM) that appears to be associated with serum lipid profiles. This study underscores that in populations where BMI is highly correlated with BF, BMI can be used as a surrogate for BF in evaluating risk of dyslipidemia. Otherwise, direct measures of BF are needed. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000251563000010
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56669
专题北京大学第一临床医学院_心血管内科
作者单位1.Childrens Mem Hosp, Div Gen Acad Pediat, Chicago, IL 60614 USA
2.Childrens Mem Res Ctr, Chicago, IL 60614 USA
3.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
4.Northwestern Univ, Feinberg Sch Med, Dept Pediat, Mary Ann J Milburn Smith Child Hlth Res Program, Chicago, IL 60611 USA
5.Beijing Univ, Affiliated Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
6.Univ Illinois, Sch Publ Hlth, Ctr Populat Genet, Chicago, IL USA
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GB/T 7714
Wang, Binyan,Necheles, Jonathan,Ouyang, Fengxiu,et al. Monozygotic co-twin analyses of body composition measurements and serum lipids[J]. PREVENTIVE MEDICINE,2007,45(5):358-365.
APA Wang, Binyan.,Necheles, Jonathan.,Ouyang, Fengxiu.,Ma, Wei.,Li, Zhiping.,...&Wang, Xiaobin.(2007).Monozygotic co-twin analyses of body composition measurements and serum lipids.PREVENTIVE MEDICINE,45(5),358-365.
MLA Wang, Binyan,et al."Monozygotic co-twin analyses of body composition measurements and serum lipids".PREVENTIVE MEDICINE 45.5(2007):358-365.
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