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Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetraacetoxy-4(20), 11-taxadiene by cell suspension cultures of Catharanthus roseus
Dai, JU; Cui, J; Zhu, WH; Guo, HZ; Ye, M; Hu, Q; Zhang, DY; Zheng, JH; Guo, D
关键词Taxane Biotransformation Cell Suspension Cultures Catharanthus Roseus Apocynaceae
刊名PLANTA MEDICA
2002-12-01
68期:12页:1113-1117
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]TUMOR-CELLS ; TAXININE
英文摘要

Catharanthus roseus cell suspension cultures were employed for the biotransformation of 2alpha,5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene (1), and four metabolites were obtained. Based on their physical and chemical data, the structures of the four metabolites were respectively elucidated as 10beta-hydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene (2), 5alpha-hydroxy-2alpha,10beta,14beta-triacetoxy-4(20),11-taxadiene (3), 6alpha,10beta-dihydroxy-2alpha,5alpha,14beta-triacetoxy-4(20),11-taxadiene (4), and 6alpha,9alpha,10beta-trihydroxy-2alpha,5alpha 14beta-triacetoxy-4(20),11-taxadiene (5), among which 3 and 5 were characterized as new taxoids. The effects of the stages of substrate addition on the biotrans formation were also investigated. The results revealed that the biotransformation rate for 1 reached 85.3% and the yield of 2 70% when 1 was administered during the mid-linear phase (9 - 12(th) day) of the cell growth cycle. On the other hand, the yield for 4 reached the highest level of 11.8% when 1 was added in the early linear phase (6(th) day).

语种英语
WOS记录号WOS:000180439100013
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56670
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Dai, JU,Cui, J,Zhu, WH,et al. Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetraacetoxy-4(20), 11-taxadiene by cell suspension cultures of Catharanthus roseus[J]. PLANTA MEDICA,2002,68(12):1113-1117.
APA Dai, JU.,Cui, J.,Zhu, WH.,Guo, HZ.,Ye, M.,...&Guo, D.(2002).Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetraacetoxy-4(20), 11-taxadiene by cell suspension cultures of Catharanthus roseus.PLANTA MEDICA,68(12),1113-1117.
MLA Dai, JU,et al."Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetraacetoxy-4(20), 11-taxadiene by cell suspension cultures of Catharanthus roseus".PLANTA MEDICA 68.12(2002):1113-1117.
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