IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China
Gao, Fei1; Zhou, Yu Jie1; Hu, Da Yi2; Zhao, Ying Xin1; Liu, Yu Yang1; Wang, Zhi Jian1; Yang, Shi Wei1; Liu, Xiao Li1
刊名PLOS ONE
2013-04-09
DOI10.1371/journal.pone.0047681
8期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DENSITY-LIPOPROTEIN-CHOLESTEROL ; ACUTE CORONARY SYNDROMES ; LIPID-LOWERING-THERAPY ; MYOCARDIAL-INFARCTION ; STATIN THERAPY ; HEART-DISEASE ; TRIAL ; HYPERCHOLESTEROLEMIA ; ATORVASTATIN ; HYPERTENSION
英文摘要

Aims: It is well-established that lipid disorder is an important cardiovascular risk factor, and failure to reach optimal lipid levels significantly contributes to the residual cardiovascular risks. However, limited information is available on the management and the attainment of recommended cholesterol targets in real-world practice in China.

Methods and Results: A nationally representative sample of 12,040 patients with dyslipidemia from 19 provinces and 84 hospitals across China were consecutively enrolled in this survey. Risk stratification and individual cholesterol target was established for all participants. This survey identified a high-risk cohort, with over 50% of patients had hypertension, 37.5% had coronary artery disease, and more than 30% had peripheral artery disease. Thirty-nine percent of all participants received lipid lowering medications. And the majority of them (94.5%) had statins (42.5% with atorvastatin, 29.0% with simvastatin, and 15.2% with rosuvastatin). However, the overall attainment for low-density lipoprotein cholesterol (LDL-C) target is low (25.8%), especially, in female (22.2%), and in patients with increased body mass index (BMI) (38.3% for BMI<18.5, 28.1% for BMI 18.5-24.9, 26.0% for BMI 25.0-29.9, and 17.4% for BMI >= 30, P<0.0001). Subgroup analysis also showed the attainment is significantly lower in patients who were stratified into high (19.9%) and very high (21.1%) risk category. In logistic regression analysis, eight factors (BMI, gender, coronary artery disease, systolic and diastolic blood pressure, hypertension, family history of premature coronary artery disease and current smoking) were identified as independent predictors of LDL-C attainment.

Conclusions: Despite the proven benefits of lipid-lowering therapies, current management of dyslipidemia continues to be unsatisfied. A considerable proportion of patients failed to achieve guideline-recommended targets in China, and this apparent treatment gap was more pronounced among patients with increased BMI, higher risk stratification and women.

语种英语
WOS记录号WOS:000317909600001
资助机构Chinese Society of Cardiology ; AstraZeneca
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56674
专题北京大学第二临床医学院
作者单位1.Capital Med Univ, An Zhen Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Gao, Fei,Zhou, Yu Jie,Hu, Da Yi,et al. Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China[J]. PLOS ONE,2013,8(4).
APA Gao, Fei.,Zhou, Yu Jie.,Hu, Da Yi.,Zhao, Ying Xin.,Liu, Yu Yang.,...&Liu, Xiao Li.(2013).Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China.PLOS ONE,8(4).
MLA Gao, Fei,et al."Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China".PLOS ONE 8.4(2013).
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