北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China
作者: Gao, Fei1; Zhou, Yu Jie1; Hu, Da Yi2; Zhao, Ying Xin1; Liu, Yu Yang1; Wang, Zhi Jian1; Yang, Shi Wei1; Liu, Xiao Li1
刊名: PLOS ONE
发表日期: 2013-04-09
DOI: 10.1371/journal.pone.0047681
卷: 8, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DENSITY-LIPOPROTEIN-CHOLESTEROL ; ACUTE CORONARY SYNDROMES ; LIPID-LOWERING-THERAPY ; MYOCARDIAL-INFARCTION ; STATIN THERAPY ; HEART-DISEASE ; TRIAL ; HYPERCHOLESTEROLEMIA ; ATORVASTATIN ; HYPERTENSION
英文摘要:

Aims: It is well-established that lipid disorder is an important cardiovascular risk factor, and failure to reach optimal lipid levels significantly contributes to the residual cardiovascular risks. However, limited information is available on the management and the attainment of recommended cholesterol targets in real-world practice in China.

Methods and Results: A nationally representative sample of 12,040 patients with dyslipidemia from 19 provinces and 84 hospitals across China were consecutively enrolled in this survey. Risk stratification and individual cholesterol target was established for all participants. This survey identified a high-risk cohort, with over 50% of patients had hypertension, 37.5% had coronary artery disease, and more than 30% had peripheral artery disease. Thirty-nine percent of all participants received lipid lowering medications. And the majority of them (94.5%) had statins (42.5% with atorvastatin, 29.0% with simvastatin, and 15.2% with rosuvastatin). However, the overall attainment for low-density lipoprotein cholesterol (LDL-C) target is low (25.8%), especially, in female (22.2%), and in patients with increased body mass index (BMI) (38.3% for BMI<18.5, 28.1% for BMI 18.5-24.9, 26.0% for BMI 25.0-29.9, and 17.4% for BMI >= 30, P<0.0001). Subgroup analysis also showed the attainment is significantly lower in patients who were stratified into high (19.9%) and very high (21.1%) risk category. In logistic regression analysis, eight factors (BMI, gender, coronary artery disease, systolic and diastolic blood pressure, hypertension, family history of premature coronary artery disease and current smoking) were identified as independent predictors of LDL-C attainment.

Conclusions: Despite the proven benefits of lipid-lowering therapies, current management of dyslipidemia continues to be unsatisfied. A considerable proportion of patients failed to achieve guideline-recommended targets in China, and this apparent treatment gap was more pronounced among patients with increased BMI, higher risk stratification and women.

语种: 英语
项目资助者: Chinese Society of Cardiology ; AstraZeneca
WOS记录号: WOS:000317909600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56674
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Med Univ, An Zhen Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China

Recommended Citation:
Gao, Fei,Zhou, Yu Jie,Hu, Da Yi,et al. Contemporary Management and Attainment of Cholesterol Targets for Patients with Dyslipidemia in China[J]. PLOS ONE,2013,8(4).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Fei]'s Articles
[Zhou, Yu Jie]'s Articles
[Hu, Da Yi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Fei]‘s Articles
[Zhou, Yu Jie]‘s Articles
[Hu, Da Yi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace