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学科主题: 临床医学
题名:
End-stage kidney disease due to haemolytic uraemic syndrome - outcomes in 241 consecutive ANZDATA registry cases
作者: Tang, Wen1,2,3; Mohandas, Janaki1,3; McDonald, Stephen P.1,4,5; Hawley, Carmel M.1,3; Badve, Sunil V.1,3; Boudville, Neil1,6; Brown, Fiona G.1,7; Clayton, Philip A.1,8,9; Wiggins, Kathryn J.1,10; Bannister, Kym M.1; Campbell, Scott B.1,3; Johnson, David W.1,3,11
关键词: Haemolytic uraemic syndrome ; Kidney Failure ; Chronic ; Outcomes ; Renal function recovery ; Renal transplantation ; Thrombotic microangiopathy
刊名: BMC NEPHROLOGY
发表日期: 2012-12-03
DOI: 10.1186/1471-2369-13-164
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: THROMBOTIC THROMBOCYTOPENIC PURPURA ; RENAL-FUNCTION ; PERITONEAL-DIALYSIS ; COMPETING RISKS ; RECOVERY ; FAILURE ; TRANSPLANTATION ; DEFICIENCY ; DISORDERS ; HUS
英文摘要:

Background: The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS).

Methods: The study included all patients with ESKD who commenced renal replacement therapy in Australia and New Zealand between 15/5/1963 and 31/12/2010, using data from the ANZDATA Registry. HUS ESKD patients were compared with matched controls with an alternative primary renal disease using propensity scores based on age, gender and treatment era. Results: Of the 58422 patients included in the study, 241 (0.4%) had ESKD secondary to HUS. HUS ESKD was independently associated with younger age, female gender and European race. Compared with matched controls, HUS ESKD was not associated with mortality on renal replacement therapy (adjusted hazard ratio [HR] 1.14, 95% CI 0.87-1.50, p = 0.34) or dialysis (HR 1.34, 95% CI 0.93-1.93, p = 0.12), but did independently predict recovery of renal function (HR 54.01, 95% CI 1.45-11.1, p = 0.008). 130 (54%) HUS patients received 166 renal allografts. Overall renal allograft survival rates were significantly lower for patients with HUS ESKD at 1 year (73% vs 91%), 5 years (62% vs 85%) and 10 years (49% vs 73%). HUS ESKD was an independent predictor of renal allograft failure (HR 2.59, 95% CI 1.70-3.95, p < 0.001). Sixteen (12%) HUS patients experienced failure of 22 renal allografts due to recurrent HUS. HUS ESKD was not independently associated with the risk of death following renal transplantation (HR 0.92, 95% CI 0.35-2.44, p = 0.87).

Conclusions: HUS is an uncommon cause of ESKD, which is associated with comparable patient survival on dialysis, an increased probability of renal function recovery, comparable patient survival post-renal transplant and a heightened risk of renal transplant graft failure compared with matched ESKD controls.

语种: 英语
所属项目编号: 30900681 ; D09050704310905 ; 76496-02
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital ; Fresenius Medical Care ; Queensland Government Health Research Fellowship ; Amgen ; Roche ; AMGEN Australia ; Genzyme Australia ; Janssen-Cilag ; Jansen Cilag ; Baxter Healthcare Pty Ltd
WOS记录号: WOS:000313589100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56675
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia
2.Royal Melbourne Hosp, Dept Nephrol, Parkville, Vic 3050, Australia
3.Princess Alexandra Hosp, Dept Renal Med, Brisbane, Qld 4102, Australia
4.ANZDATA Registry, Adelaide, SA, Australia
5.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
6.Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
7.Univ Adelaide, Cent No Adelaide Renal Serv, Dept Nephrol & Transplantat Serv, Adelaide, SA, Australia
8.Univ Adelaide, Cent No Adelaide Transplantat Serv, Dept Nephrol & Transplantat Serv, Adelaide, SA, Australia
9.Univ Western Australia, Sir Charles Gairdner Hosp Unit, Sch Med & Pharmacol, Perth, WA 6009, Australia
10.Monash Med Ctr, Dept Nephrol, Melbourne, Vic, Australia
11.Royal Prince Alfred Hosp, Dept Renal Med, Sydney, NSW, Australia

Recommended Citation:
Tang, Wen,Mohandas, Janaki,McDonald, Stephen P.,et al. End-stage kidney disease due to haemolytic uraemic syndrome - outcomes in 241 consecutive ANZDATA registry cases[J]. BMC NEPHROLOGY,2012,13.
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