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学科主题: 临床医学
题名:
Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans
作者: Li, Tianrun1; Cao, Hengchang2,3; Zhuang, Jinman1; Wan, Jun4,5; Guan, Ming6; Yu, Bo2; Li, Xuan1; Zhang, Wei2,5
关键词: MicroRNAs ; Arteriosclerosis obliterans (ASO) ; Peripheral arterial disease (PAD)
刊名: CLINICA CHIMICA ACTA
发表日期: 2011-01-14
DOI: 10.1016/j.cca.2010.09.029
卷: 412, 期:1-2, 页:66-70
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: MICRORNA EXPRESSION ; ANGIOGENESIS ; CELLS ; DISEASE ; DICER
英文摘要:

Background: Arteriosclerosis obliterans (ASO) is a kind of peripheral arterial disease. Most patients with ASO have no apparent clinical symptoms early on, but a diagnosis at the early stage is essential to prevent progression. Unfortunately, the specific and sensitive markers for ASO are still lacking currently. In this study, using both tissue samples and blood samples obtained from ASO patients, we aim to find a cluster of miRNAs that can be used as new risk-markers for the diagnosis of ASO in the earlier stages.

Methods: We enrolled 104 patients diagnosed with ASO and 105 age-matched controls. We examined the expression levels of a series of miRNAs in both intima samples and serum samples from these patients.

Results: Levels of miR-21. miR-130a, miR-27b, let-7f and miR-210 significantly increased, while levels of miR-221 and miR-222 significantly decreased in the sclerotic samples compared with normal samples. Significant increase of miR-130a, miR-27b and miR-210 expression was observed in the serum samples of ASO patients. Moreover, the expression of miR-130a and miR-27b in sera of ASO patients was positively correlated with Fontaine stages.

Conclusions: The serum levels of miR-130a, miR-27b and miR-210 may serve as potential biomarkers for early stage ASO. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
项目资助者: Peking University Third Hospital ; Shenzhen Science and Technology Project
WOS记录号: WOS:000285655700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56677
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
2.Peking Univ, Hosp 3, Dept Intervent & Vasc Surg, Beijing 100871, Peoples R China
3.Hong Kong Univ Sci & Technol, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Surg, Shenzhen, Guangdong, Peoples R China
5.Hong Kong Univ Sci & Technol, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Li, Tianrun,Cao, Hengchang,Zhuang, Jinman,et al. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans[J]. CLINICA CHIMICA ACTA,2011,412(1-2):66-70.
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