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学科主题: 临床医学
题名:
Clinical comparison of ibutilide and propafenone for converting atrial flutter
作者: Sun, JL; Guo, JH; Zhang, N; Zhang, HC; Zhang, P
关键词: atrial flutter ; ibutilide ; propafenone ; conversion ; tolerability ; arrhythmia
刊名: CARDIOVASCULAR DRUGS AND THERAPY
发表日期: 2005
DOI: 10.1007/s10557-005-6898-y
卷: 19, 期:1, 页:57-64
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]: Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]: INTRAVENOUS IBUTILIDE ; ANTIARRHYTHMIC AGENT ; CONVERSION EFFICACY ; CLASS-I ; FIBRILLATION ; TERMINATION ; ARRHYTHMIAS ; SOTALOL ; DRUG ; PROCAINAMIDE
英文摘要:

Objective: To evaluate the efficacy and safety of intravenous ibutilide and propafenone for immediate treatment of atrial flutter.

Methods: Forty patients with atrial flutter with an arrhythmia duration of three hours to 90 days were randomized to receive up to two 10-minute infusions of ibutilide (1 and 1 mg) or propafenone (70 and 70 mg) with a 10-minute interval.

Results: Ibutilide was superior to propafenone for treating atrial flutter (90% vs. 30%, p < 0.01). The median conversion time in the ibutilide group was 11 min (the 25th and 75th percentile was 10 and 45 min), and the median conversion time in the propafenone group was 35 min (range 20-55 min). In all patients, the duration of arrhythmia before treatment was a predictor of arrhythmia termination, although this was more obvious in the group that received ibutilide. Conversion of atrial flutter by ibutilide was characterized mainly by increased cycle length variability. Bradycardia (2/20) and hypotension (4/20) were more common side effects with propafenone. Of 20 patients given ibutilide, 8 (40%) who developed monomorphic ventricular extrasystoles or repetitive atrial flutter with aberrant conduction tachycardia, no one required any specific treatment except for the interruption of ibutilide infusion.

Conclusion: Ibutilide is highly effective for rapidly terminating atrial flutter. This new class III drug, under monitored conditions, is a potential alternative to currently available cardioversion options.

语种: 英语
WOS记录号: WOS:000229001300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56683
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Cardiol, Electrophysiol Grp, Beijing 100044, Peoples R China

Recommended Citation:
Sun, JL,Guo, JH,Zhang, N,et al. Clinical comparison of ibutilide and propafenone for converting atrial flutter[J]. CARDIOVASCULAR DRUGS AND THERAPY,2005,19(1):57-64.
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