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学科主题: 临床医学
题名:
The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes
作者: Tan, Y.1,2,3; Zhang, J.-J.1,2,3; Liu, G.1,2,3; Zhang, H.1,2,3; Zhao, M.-H.1,2,3
关键词: biomarker ; IgA nephropathy ; sIgA
刊名: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
发表日期: 2009-04-01
DOI: 10.1111/j.1365-2249.2008.03868.x
卷: 156, 期:1, 页:111-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: SERUM ; GLOMERULONEPHRITIS ; KIDNEYS ; PROTEIN ; DISEASE ; RATIO
英文摘要:

Recent studies have demonstrated deposition of secretory immunoglobulin A (sIgA) in glomeruli of some patients with IgA nephropathy (IgAN). The aim of this study is to investigate the levels of urinary sIgA in IgAN patients with different pathological phenotypes and whether it could be used as a non-invasive biomarker for assessment of kidney injury in IgAN. Urine samples from 202 patients with IgAN were collected on the day of renal biopsy. Forty-eight fulfilled the histopathological criteria of Haas-I or II (group 1), 60 fulfilled Haas-III (group 2) and 94 patients fulfilled Haas-IV or V (group 3). Urine samples from 60 healthy sex- and age-matched volunteers with negative urinalysis were collected as normal controls. Urinary sIgA was detected by sandwich enzyme-linked immunosorbent assay and was corrected by urinary creatinine. In comparison with normal controls, the levels of urinary sIgA were significantly higher in IgAN [2.22 (0-43.82) mu g/mg Cr versus 1.08 (0-16.49) mu g/mg Cr, P < 0.001]. The levels of urinary sIgA were significantly higher in group 3 than that in group 2 and group 1 [3.54 (0-43.82) mu g/mg Cr versus 1.63 (0-15.88) mu g/mg Cr versus 0.91 (0-11.79), P < 0.001], and group 2 than group 1 (P = 0.014). The levels of urinary sIgA were associated positively with proteinuria (r = 0.443, P < 0.001), serum creatinine (r = 0.376, P < 0.001) and histopathological parameters, such as ratio of global sclerosis (r = 0.356, P < 0.001), ratio of total crescents (r = 0.339, P < 0.001) and ratios of cellular crescents (r = 0.231, P < 0.001). The levels of urinary sIgA were associated closely with histopathological phenotypes of IgAN and might be used as a non-invasive biomarker to evaluate kidney injury in IgAN.

语种: 英语
所属项目编号: 2007BAI04B10
项目资助者: National Key Technology RD Programme ; People&prime ; s Republic of China
WOS记录号: WOS:000264065200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56684
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China

Recommended Citation:
Tan, Y.,Zhang, J.-J.,Liu, G.,et al. The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2009,156(1):111-116.
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