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Improving Efficiency of Adriamycin Crossing Blood Brain Barrier by Combination of Thermosensitive Liposomes and Hyperthermia
Gong, Wei1; Wang, Zhiyuan1; Liu, Nan1; Lin, Wen1; Wang, Xingping2; Xu, Dong2; Liu, Hongyu2; Zeng, Chunying2; Xie, Xiangyang1; Mei, Xingguo1; Lue, Wanliang3
关键词Thermosensitive Liposome Hyperthermia Blood Brain Barrier Adriamycin Hydrochloride
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2011-07-01
34期:7页:1058-1064
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者Major State Basic Research Development Program of China ; Important National Science and Technology Specific Projects ; Major State Basic Research Development Program of China ; Important National Science and Technology Specific Projects
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY ; IN-VITRO ; PERMEABILITY ; MODULATION ; TRANSPORT ; SURVIVAL ; RELEASE ; RAT
英文摘要

Adriamycin (ADM)-encapsulated thermosensitive liposomes (ts-lip-ADM) and common liposomes (lip-ADM) were developed and evaluated. The encapsulation efficiency of the two liposomes were above 99%, and the average sizes of liposomes were about 120 nm. Temperature-dependent drug release from loaded liposomes in vitro was investigated: more than 90% of loaded ADM was released from ts-lip-ADM within 30 min at 42 C, while less than 3% was released from lip-ADM at 42 degrees C beyond 120 min. An in vitro model of blood brain barrier (BBB) was established and evaluated by permeability and transendothelial electrical resistance (TEER). The model was employed to study the permeability of liposomes in vitro. The permeability of ts-lip-ADM could be increased significantly after the temperature was raised to 42 C, which was about 10-16, 22-38, 38-45, 50-105 fold to that of ts-lip-ADM (37 degrees C), lip-ADM (42 degrees C), lip-ADM (37 degrees C) and free ADM, respectively. C6 glioma-bearing mice model was developed and used to evaluate body distribution and anti-tumor efficacy in vivo. Mice were IV injected at a drug dose of 10 mg/kg. After administration the heads of mice were heated in water bath at 42 degrees C for 30 min. The maximum brain concentration of ts-lip-ADM was 6.4, 3.7 fold compared with that of ADM solution and lip-ADM, respectively. The survival time of mice administered ts-lip-ADM (44 d) was remarkably longer than that of other three groups. This study indicates that ADM-encapsulated thermosensitive liposomes combined hyperthermia could enhance ADM delivery across BBB and prolong survival time of glioma-bearing mice.

语种英语
所属项目编号2007CB935800 ; 2009ZX09301-002
资助者Major State Basic Research Development Program of China ; Important National Science and Technology Specific Projects ; Major State Basic Research Development Program of China ; Important National Science and Technology Specific Projects
WOS记录号WOS:000292342100019
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56689
专题北京大学药学院
作者单位1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Wuhan Inst Technol, Wuhan 430074, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gong, Wei,Wang, Zhiyuan,Liu, Nan,et al. Improving Efficiency of Adriamycin Crossing Blood Brain Barrier by Combination of Thermosensitive Liposomes and Hyperthermia[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(7):1058-1064.
APA Gong, Wei.,Wang, Zhiyuan.,Liu, Nan.,Lin, Wen.,Wang, Xingping.,...&Lue, Wanliang.(2011).Improving Efficiency of Adriamycin Crossing Blood Brain Barrier by Combination of Thermosensitive Liposomes and Hyperthermia.BIOLOGICAL & PHARMACEUTICAL BULLETIN,34(7),1058-1064.
MLA Gong, Wei,et al."Improving Efficiency of Adriamycin Crossing Blood Brain Barrier by Combination of Thermosensitive Liposomes and Hyperthermia".BIOLOGICAL & PHARMACEUTICAL BULLETIN 34.7(2011):1058-1064.
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