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学科主题: 公共卫生
题名:
Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers
作者: Wang, Tian-Cheng2; Song, Yan-Shuang1; Wang, Hui3; Zhang, Ji4; Yu, Shan-Fa5; Gu, Yong-En1; Chen, Tian1; Wang, Yun1; Shen, Hui-Qi1; Jia, Guang1
关键词: Chromium ; Folate ; Oxidative DNA damage ; DNA hypomethylation ; Workers
刊名: JOURNAL OF HAZARDOUS MATERIALS
发表日期: 2012-04-30
DOI: 10.1016/j.jhazmat.2012.02.024
卷: 213, 页:440-446
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Environmental ; Engineering, Civil ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
关键词[WOS]: FOLIC-ACID ; HEXAVALENT CHROMIUM ; ELECTROPLATING WORKERS ; EXPOSED WORKERS ; LUNG-CANCER ; METHYLATION ; STRESS ; EXPRESSION ; CARCINOGENESIS ; GENOTOXICITY
英文摘要:

Exposure to hexavalent chromium [Cr (VI)] can cause DNA damage, genetic instability and increase the risk of cancer development. Folate deficiency affects DNA methylation and reduces the stability of the genetic material. However, the correlation between folate deficiency and DNA damage has never been clearly elucidated in chromate workers. In this study, we recruited one hundred and fifteen workers from chromate producing facilities as testing subjects and sixty local residents without chromium exposure history served as controls. The results showed an evident accumulation of Cr in peripheral red blood cells accompanied by a significantly decreased serum folate in chromate exposed workers. The decreased serum folate was associated with an increased urinary 8-hydroxy-2′-deoxyguanosine, DNA strand breaks and global DNA hypomethylation. These findings suggest that chronic occupational chromate exposure could induce folate depletion, which may further promote DNA damages and global DNA hypomethylation. Adequate folate supplement may provide benefit to chromate sufferers in stabilization of genetic material and reduce the risk of cancer development. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81072281 ; 200902006
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000302893100055
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56691
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Clin Labs, Hosp 3, Beijing 100191, Peoples R China
3.Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA
4.Ctr Dis Control & Prevent Jinan City, Jinan 250013, Shandong, Peoples R China
5.Inst Occupat Med Henan Prov, Zhengzhou 450052, Henan Province, Peoples R China

Recommended Citation:
Wang, Tian-Cheng,Song, Yan-Shuang,Wang, Hui,et al. Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers[J]. JOURNAL OF HAZARDOUS MATERIALS,2012,213:440-446.
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