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Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers
Wang, Tian-Cheng2; Song, Yan-Shuang1; Wang, Hui3; Zhang, Ji4; Yu, Shan-Fa5; Gu, Yong-En1; Chen, Tian1; Wang, Yun1; Shen, Hui-Qi1; Jia, Guang1
关键词Chromium Folate Oxidative Dna Damage Dna Hypomethylation Workers
刊名JOURNAL OF HAZARDOUS MATERIALS
2012-04-30
DOI10.1016/j.jhazmat.2012.02.024
213页:440-446
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Environmental ; Engineering, Civil ; Environmental Sciences
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
关键词[WOS]FOLIC-ACID ; HEXAVALENT CHROMIUM ; ELECTROPLATING WORKERS ; EXPOSED WORKERS ; LUNG-CANCER ; METHYLATION ; STRESS ; EXPRESSION ; CARCINOGENESIS ; GENOTOXICITY
英文摘要

Exposure to hexavalent chromium [Cr (VI)] can cause DNA damage, genetic instability and increase the risk of cancer development. Folate deficiency affects DNA methylation and reduces the stability of the genetic material. However, the correlation between folate deficiency and DNA damage has never been clearly elucidated in chromate workers. In this study, we recruited one hundred and fifteen workers from chromate producing facilities as testing subjects and sixty local residents without chromium exposure history served as controls. The results showed an evident accumulation of Cr in peripheral red blood cells accompanied by a significantly decreased serum folate in chromate exposed workers. The decreased serum folate was associated with an increased urinary 8-hydroxy-2′-deoxyguanosine, DNA strand breaks and global DNA hypomethylation. These findings suggest that chronic occupational chromate exposure could induce folate depletion, which may further promote DNA damages and global DNA hypomethylation. Adequate folate supplement may provide benefit to chromate sufferers in stabilization of genetic material and reduce the risk of cancer development. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000302893100055
项目编号81072281 ; 200902006
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56691
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Clin Labs, Hosp 3, Beijing 100191, Peoples R China
3.Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA
4.Ctr Dis Control & Prevent Jinan City, Jinan 250013, Shandong, Peoples R China
5.Inst Occupat Med Henan Prov, Zhengzhou 450052, Henan Province, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tian-Cheng,Song, Yan-Shuang,Wang, Hui,et al. Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers[J]. JOURNAL OF HAZARDOUS MATERIALS,2012,213:440-446.
APA Wang, Tian-Cheng.,Song, Yan-Shuang.,Wang, Hui.,Zhang, Ji.,Yu, Shan-Fa.,...&Jia, Guang.(2012).Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers.JOURNAL OF HAZARDOUS MATERIALS,213,440-446.
MLA Wang, Tian-Cheng,et al."Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers".JOURNAL OF HAZARDOUS MATERIALS 213(2012):440-446.
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