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学科主题: 基础医学
题名:
Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice
作者: Bai, H; Yang, J; Qiu, HY; Wang, SH; Fan, YJ; Han, XB; Xie, SS; Yang, X
关键词: chemokine ; Chlamydia trachomatis ; CXCR-2 ; gene knockout ; neutrophil
刊名: IMMUNOLOGY
发表日期: 2005-02-01
DOI: 10.1111/j.1365-2567.2004.02088.x
卷: 114, 期:2, 页:246-254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: RESPIRATORY-DISTRESS SYNDROME ; LISTERIA-MONOCYTOGENES ; MYCOBACTERIUM-AVIUM ; PROTECTIVE IMMUNITY ; INFLAMMATORY CELLS ; LUNG INFECTION ; HOST-DEFENSE ; BEIGE MICE ; RECEPTOR ; TISSUE
英文摘要:

Previous studies have shown that chlamydial infection is accompanied by significant infiltration of neutrophils at the site of infection. However, the role of neutrophils in host defence against chlamydial infection is not clearly understood. Using genetically different inbred mouse strains and CXCR-2 gene knockout (KO) mice, we examined the mechanism for neutrophil recruitment and the role of neutrophils during chlamydial lung infection. Our data showed that C3H mice exhibited significantly higher and more persistent neutrophil infiltration in the lung than did C57BL/6 mice following Chlamydia trachomatis mouse pneumonitis infection. The massive neutrophil infiltration in C3H mice was paralleled by high-level expression of CXCR-2 and its ligands, CXC chemokines (macrophage inflammatory protein 2, cytokine-induced neutrophil attractant (KC) and lipopolysaccharide-induced CXC chemokine), and proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-1 and interleukin-6) in the lung. Although much greater infiltration of neutrophils was observed in C3H mice than in C57BL/6 mice, the former mice had more severe disease and higher in vivo chlamydial growth than the latter. Moreover, CXCR-2 KO mice, which revealed a dramatic reduction in neutrophil activity, showed comparable chlamydial infection to wild-type mice. These results suggest that neutrophils are not efficient for controlling chlamydial lung infection.

语种: 英语
WOS记录号: WOS:000226528500010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56692
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Univ Manitoba, Fac Med, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Bai, H,Yang, J,Qiu, HY,et al. Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice[J]. IMMUNOLOGY,2005,114(2):246-254.
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