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学科主题: 基础医学
题名:
Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells
作者: Qiu, XY; Zhu, XH; Zhang, L; Mao, YT; Zhang, J; Hao, P; Li, GH; Lv, P; Li, ZX; Sun, X; Wu, LM; Zheng, J; Deng, YQ; Hou, CM; Tang, PX; Zhang, SR; Zhang, YH
刊名: CANCER RESEARCH
发表日期: 2003-10-01
卷: 63, 期:19, 页:6488-6495
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: LUNG-CANCER ; EXPRESSION ; ANTIGENS
英文摘要:

Immunoglobulins (Igs) are found thus far only to be produced by differentiated B lymphocytes. By immunohistochemistry analysis, in situ hybridization, and laser capture microdissection-assisted single-cell PCR, we demonstrate that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, as well as some normal lung tissues, also produce IgG in both cytoplasmic and secreted forms. Furthermore, blockade of tumor-derived IgG by either antisense DNA or antihuman IgG antibody increased programmed cell death and inhibited growth of cancer cells in vitro. More importantly, administration of antihuman IgG antibody also suppressed the growth of an IgG-secreting carcinoma line in immunodeficient nude mice. Our results support a role of tumor-derived IgG as growth factor for epithelial cancers. Prevalent expression of IgG in human carcinomas and its growth-promoting functions may have important implications in growth regulation and targeted therapy of human cancers.

语种: 英语
WOS记录号: WOS:000185967700056
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56696
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Beijing Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
3.Chinese Acad Med Sci, Inst Canc, Dept Immunol, Beijing 100021, Peoples R China
4.Peking Union Med Coll, Beijing 10021, Peoples R China

Recommended Citation:
Qiu, XY,Zhu, XH,Zhang, L,et al. Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells[J]. CANCER RESEARCH,2003,63(19):6488-6495.
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