学科主题基础医学
Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells
Qiu, XY; Zhu, XH; Zhang, L; Mao, YT; Zhang, J; Hao, P; Li, GH; Lv, P; Li, ZX; Sun, X; Wu, LM; Zheng, J; Deng, YQ; Hou, CM; Tang, PX; Zhang, SR; Zhang, YH
刊名CANCER RESEARCH
2003-10-01
63期:19页:6488-6495
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]LUNG-CANCER ; EXPRESSION ; ANTIGENS
英文摘要

Immunoglobulins (Igs) are found thus far only to be produced by differentiated B lymphocytes. By immunohistochemistry analysis, in situ hybridization, and laser capture microdissection-assisted single-cell PCR, we demonstrate that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, as well as some normal lung tissues, also produce IgG in both cytoplasmic and secreted forms. Furthermore, blockade of tumor-derived IgG by either antisense DNA or antihuman IgG antibody increased programmed cell death and inhibited growth of cancer cells in vitro. More importantly, administration of antihuman IgG antibody also suppressed the growth of an IgG-secreting carcinoma line in immunodeficient nude mice. Our results support a role of tumor-derived IgG as growth factor for epithelial cancers. Prevalent expression of IgG in human carcinomas and its growth-promoting functions may have important implications in growth regulation and targeted therapy of human cancers.

语种英语
WOS记录号WOS:000185967700056
引用统计
被引频次:114[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56696
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Beijing Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
3.Chinese Acad Med Sci, Inst Canc, Dept Immunol, Beijing 100021, Peoples R China
4.Peking Union Med Coll, Beijing 10021, Peoples R China
推荐引用方式
GB/T 7714
Qiu, XY,Zhu, XH,Zhang, L,et al. Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells[J]. CANCER RESEARCH,2003,63(19):6488-6495.
APA Qiu, XY.,Zhu, XH.,Zhang, L.,Mao, YT.,Zhang, J.,...&Zhang, YH.(2003).Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells.CANCER RESEARCH,63(19),6488-6495.
MLA Qiu, XY,et al."Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells".CANCER RESEARCH 63.19(2003):6488-6495.
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