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学科主题临床医学
Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis
Tian, Maolin1,6; Wan, Yuanlian1; Tang, Jianqiang1; Li, Hui1; Yu, Ge1; Zhu, Jing1; Ji, Shiqi2; Guo, Hui2; Zhang, Nan2; Li, Weiren2; Gai, Junwei2; Wang, Lei2; Dai, Lifang3; Liu, Die3; Lei, Liandi4; Zhu, Shigong5
关键词Mmps Colon Cancer Tissue Factor Hepatic Metastasis Autophagy Unfolded Protein Response (Upr) Perk
刊名CANCER BIOLOGY & THERAPY
2011-11-15
DOI10.4161/cbt.12.10.17697
12期:10页:896-907
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; PROTEIN-SYNTHESIS ; DISEASE ; GENES ; CELLS
英文摘要

Tissue factor (TF) is a significant risk factor for hepatic metastasis in patients with colorectal cancer (CRC). However, the mechanism by which TF promotes hepatic metastasis in CRC remains elusive. In this study, we first confirmed that TF expression was significantly correlated with lymph node metastasis, hepatic metastasis and TNM staging in clinical CRC samples, and found that TF expression in colon cancer cell lines was correlated with the invasion ability. Next, by employing TF-overexpressing LOVO cell line as a model we demonstrated that lentivirus mediated knockdown of TF suppressed the migration and invasion of LOVO cells in vitro, and hepatic metastasis of colorectal cancer in nude mice orthotopic model. Mechanistically, we found that TF knockdown decreases colony formation ability and induced autophagy and apoptosis of LOVO cells, and this was at least partly mediated by the activation of unfolded protein response/PERK signaling. In conclusion, our data provide new insight into hepatic metastasis of CRC. Agents targeting TF should be developed as adjuvant therapeutics for CRC metastasis.

语种英语
WOS记录号WOS:000297165200006
项目编号30872469 ; 30801092
资助机构National Natural Science Foundation of China ; National Natural Science Youth Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56698
专题北京大学第一临床医学院_普通外科
北京大学基础医学院
北京大学中国卫生发展研究中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Peking Univ First Hosp, Dept Urol, Beijing, Peoples R China
2.Peking Univ First Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Anal Ctr, Beijing 100871, Peoples R China
4.Peking Univ First Hosp, Dept Gen Surg, Beijing, Peoples R China
5.Peking Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing, Peoples R China
6.Capital Med Univ, Beijing Chaoyang Hosp, Dept Hernia & Abdominal Wall Surg, Beijing, Peoples R China
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Tian, Maolin,Wan, Yuanlian,Tang, Jianqiang,et al. Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis[J]. CANCER BIOLOGY & THERAPY,2011,12(10):896-907.
APA Tian, Maolin.,Wan, Yuanlian.,Tang, Jianqiang.,Li, Hui.,Yu, Ge.,...&Zhu, Shigong.(2011).Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis.CANCER BIOLOGY & THERAPY,12(10),896-907.
MLA Tian, Maolin,et al."Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis".CANCER BIOLOGY & THERAPY 12.10(2011):896-907.
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