北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科  > 期刊论文
学科主题: 临床医学
题名:
Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis
作者: Tian, Maolin1,6; Wan, Yuanlian1; Tang, Jianqiang1; Li, Hui1; Yu, Ge1; Zhu, Jing1; Ji, Shiqi2; Guo, Hui2; Zhang, Nan2; Li, Weiren2; Gai, Junwei2; Wang, Lei2; Dai, Lifang3; Liu, Die3; Lei, Liandi4; Zhu, Shigong5
关键词: MMPs ; colon cancer ; tissue factor ; hepatic metastasis ; autophagy ; unfolded protein response (UPR) ; PERK
刊名: CANCER BIOLOGY & THERAPY
发表日期: 2011-11-15
DOI: 10.4161/cbt.12.10.17697
卷: 12, 期:10, 页:896-907
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; PROTEIN-SYNTHESIS ; DISEASE ; GENES ; CELLS
英文摘要:

Tissue factor (TF) is a significant risk factor for hepatic metastasis in patients with colorectal cancer (CRC). However, the mechanism by which TF promotes hepatic metastasis in CRC remains elusive. In this study, we first confirmed that TF expression was significantly correlated with lymph node metastasis, hepatic metastasis and TNM staging in clinical CRC samples, and found that TF expression in colon cancer cell lines was correlated with the invasion ability. Next, by employing TF-overexpressing LOVO cell line as a model we demonstrated that lentivirus mediated knockdown of TF suppressed the migration and invasion of LOVO cells in vitro, and hepatic metastasis of colorectal cancer in nude mice orthotopic model. Mechanistically, we found that TF knockdown decreases colony formation ability and induced autophagy and apoptosis of LOVO cells, and this was at least partly mediated by the activation of unfolded protein response/PERK signaling. In conclusion, our data provide new insight into hepatic metastasis of CRC. Agents targeting TF should be developed as adjuvant therapeutics for CRC metastasis.

语种: 英语
所属项目编号: 30872469 ; 30801092
项目资助者: National Natural Science Foundation of China ; National Natural Science Youth Foundation of China
WOS记录号: WOS:000297165200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56698
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ First Hosp, Dept Urol, Beijing, Peoples R China
2.Peking Univ First Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Anal Ctr, Beijing 100871, Peoples R China
4.Peking Univ First Hosp, Dept Gen Surg, Beijing, Peoples R China
5.Peking Univ Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing, Peoples R China
6.Capital Med Univ, Beijing Chaoyang Hosp, Dept Hernia & Abdominal Wall Surg, Beijing, Peoples R China

Recommended Citation:
Tian, Maolin,Wan, Yuanlian,Tang, Jianqiang,et al. Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis[J]. CANCER BIOLOGY & THERAPY,2011,12(10):896-907.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tian, Maolin]'s Articles
[Wan, Yuanlian]'s Articles
[Tang, Jianqiang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tian, Maolin]‘s Articles
[Wan, Yuanlian]‘s Articles
[Tang, Jianqiang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace