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学科主题口腔医学
Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ
Wang, X. D.1,2; Cui, S. J.1,2; Liu, Y.1,2; Luo, Q.1,2; Du, R. J.1,2; Kou, X. X.1,2; Zhang, J. N.1,2; Zhou, Y. H.1,2; Gan, Y. H.3
关键词Temporomandibular Joint Temporomandibular Disorders Disc Displacement Arthritis Biomechanics Collagen
刊名JOURNAL OF DENTAL RESEARCH
2014-11-01
DOI10.1177/0022034514552825
93期:11页:1170-1176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]TEMPOROMANDIBULAR-JOINT DISC ; AGE-RELATED-CHANGES ; INTERNAL DERANGEMENT ; VISCOELASTIC PROPERTIES ; ARTICULAR DISC ; OSTEOARTHROSIS ; RAT ; DISPLACEMENT ; COLLAGEN ; COMPRESSION
英文摘要

Temporomandibular joint (TMJ) discs frequently undergo degenerative changes in arthritis. However, the biomechanical properties of pathogenic discs remain to be explored. In this study, we evaluated the effects of chronic inflammation on the biomechanical properties of TMJ discs in rats. Chronic inflammation of TMJs was induced by double intra-articular injections of complete Freund′s adjuvant for 5 weeks, and biomechanical properties and ultrastructure of the discs were examined by mechanical testing, scanning electron microscopy, and transmission electron microscopy. The instantaneous compressive moduli of the anterior and posterior bands of discs in inflamed TMJs were decreased significantly compared with those in the control group. The instantaneous tensile moduli of the discs of inflamed TMJs also showed significant decreases in both the anterior-posterior and mesial-lateral directions. The relaxation moduli of the discs of inflamed TMJs showed nearly the same tendency as the instantaneous moduli. The surfaces of the discs of inflamed TMJs became rough and porous due to the loss of the superficial gel-like stratum, with many collagen fibers exposed and degradation of the sub-superficial collagen fibrils. Our results suggested that chronic inflammation of TMJ could lead to deterioration of mechanical properties and alteration of disc ultrastructure, which might contribute to TMJ disc displacement.

语种英语
WOS记录号WOS:000343975100018
项目编号2013DF B30360 ; 81300850
资助机构International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56701
专题北京大学口腔医学院_牙周科
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, X. D.,Cui, S. J.,Liu, Y.,et al. Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ[J]. JOURNAL OF DENTAL RESEARCH,2014,93(11):1170-1176.
APA Wang, X. D..,Cui, S. J..,Liu, Y..,Luo, Q..,Du, R. J..,...&Gan, Y. H..(2014).Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ.JOURNAL OF DENTAL RESEARCH,93(11),1170-1176.
MLA Wang, X. D.,et al."Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ".JOURNAL OF DENTAL RESEARCH 93.11(2014):1170-1176.
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