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学科主题: 口腔医学
题名:
Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ
作者: Wang, X. D.1,2; Cui, S. J.1,2; Liu, Y.1,2; Luo, Q.1,2; Du, R. J.1,2; Kou, X. X.1,2; Zhang, J. N.1,2; Zhou, Y. H.1,2; Gan, Y. H.3
关键词: temporomandibular joint ; temporomandibular disorders ; disc displacement ; arthritis ; biomechanics ; collagen
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2014-11-01
DOI: 10.1177/0022034514552825
卷: 93, 期:11, 页:1170-1176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: TEMPOROMANDIBULAR-JOINT DISC ; AGE-RELATED-CHANGES ; INTERNAL DERANGEMENT ; VISCOELASTIC PROPERTIES ; ARTICULAR DISC ; OSTEOARTHROSIS ; RAT ; DISPLACEMENT ; COLLAGEN ; COMPRESSION
英文摘要:

Temporomandibular joint (TMJ) discs frequently undergo degenerative changes in arthritis. However, the biomechanical properties of pathogenic discs remain to be explored. In this study, we evaluated the effects of chronic inflammation on the biomechanical properties of TMJ discs in rats. Chronic inflammation of TMJs was induced by double intra-articular injections of complete Freund′s adjuvant for 5 weeks, and biomechanical properties and ultrastructure of the discs were examined by mechanical testing, scanning electron microscopy, and transmission electron microscopy. The instantaneous compressive moduli of the anterior and posterior bands of discs in inflamed TMJs were decreased significantly compared with those in the control group. The instantaneous tensile moduli of the discs of inflamed TMJs also showed significant decreases in both the anterior-posterior and mesial-lateral directions. The relaxation moduli of the discs of inflamed TMJs showed nearly the same tendency as the instantaneous moduli. The surfaces of the discs of inflamed TMJs became rough and porous due to the loss of the superficial gel-like stratum, with many collagen fibers exposed and degradation of the sub-superficial collagen fibrils. Our results suggested that chronic inflammation of TMJ could lead to deterioration of mechanical properties and alteration of disc ultrastructure, which might contribute to TMJ disc displacement.

语种: 英语
所属项目编号: 2013DF B30360 ; 81300850
项目资助者: International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000343975100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56701
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
Wang, X. D.,Cui, S. J.,Liu, Y.,et al. Deterioration of Mechanical Properties of Discs in Chronically Inflamed TMJ[J]. JOURNAL OF DENTAL RESEARCH,2014,93(11):1170-1176.
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