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学科主题: 口腔医学
题名:
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma
作者: Guo, Xiao-Hong1,2; Wang, Jin-Yu1,2; Gao, Yan3; Gao, Min4; Yu, Guang-Yan4; Xiang, Ruo-Lan1,2; Li, Li1,2; Yang, Ning-Yan4; Cong, Xin1,2; Xu, Xiao-Yan5; Li, Sheng-Lin4; Peng, Xin4; Wu, Li-Ling1,2
刊名: CANCER SCIENCE
发表日期: 2013-02-01
DOI: 10.1111/cas.12077
卷: 104, 期:2, 页:206-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MOLECULAR-WEIGHT ADIPONECTIN ; TYPE-2 DIABETIC-PATIENTS ; PLASMA ADIPONECTIN ; SERUM ADIPONECTIN ; COLORECTAL-CANCER ; BREAST-CANCER ; CIRCULATING ADIPONECTIN ; ENDOMETRIAL CANCER ; PROSTATE-CANCER ; GASTRIC-CANCER
英文摘要:

Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n=37) and western blot (n=30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 +/- 2.4 vs 8.4 +/- 3.5g/mL, P<0.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor-node-metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the TSCC patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of SCC15 cells invitro. These results indicate that a decreased adiponectin level is associated with risk of TSCC. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of TSCC.

语种: 英语
所属项目编号: 81141032 ; 30973316
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000314983800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56706
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Physiol & Pathophysiol, Ctr Salivary Gland Dis,Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
4.Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Guo, Xiao-Hong,Wang, Jin-Yu,Gao, Yan,et al. Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma[J]. CANCER SCIENCE,2013,104(2):206-213.
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