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学科主题口腔医学
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma
Guo, Xiao-Hong1,2; Wang, Jin-Yu1,2; Gao, Yan3; Gao, Min4; Yu, Guang-Yan4; Xiang, Ruo-Lan1,2; Li, Li1,2; Yang, Ning-Yan4; Cong, Xin1,2; Xu, Xiao-Yan5; Li, Sheng-Lin4; Peng, Xin4; Wu, Li-Ling1,2
刊名CANCER SCIENCE
2013-02-01
DOI10.1111/cas.12077
104期:2页:206-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MOLECULAR-WEIGHT ADIPONECTIN ; TYPE-2 DIABETIC-PATIENTS ; PLASMA ADIPONECTIN ; SERUM ADIPONECTIN ; COLORECTAL-CANCER ; BREAST-CANCER ; CIRCULATING ADIPONECTIN ; ENDOMETRIAL CANCER ; PROSTATE-CANCER ; GASTRIC-CANCER
英文摘要

Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n=37) and western blot (n=30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 +/- 2.4 vs 8.4 +/- 3.5g/mL, P<0.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor-node-metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the TSCC patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of SCC15 cells invitro. These results indicate that a decreased adiponectin level is associated with risk of TSCC. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of TSCC.

语种英语
WOS记录号WOS:000314983800011
项目编号81141032 ; 30973316
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56706
专题北京大学口腔医学院_口腔病理科
北京大学基础医学院
北京大学口腔医学院_外科
作者单位1.Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Physiol & Pathophysiol, Ctr Salivary Gland Dis,Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
4.Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Guo, Xiao-Hong,Wang, Jin-Yu,Gao, Yan,et al. Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma[J]. CANCER SCIENCE,2013,104(2):206-213.
APA Guo, Xiao-Hong.,Wang, Jin-Yu.,Gao, Yan.,Gao, Min.,Yu, Guang-Yan.,...&Wu, Li-Ling.(2013).Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma.CANCER SCIENCE,104(2),206-213.
MLA Guo, Xiao-Hong,et al."Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma".CANCER SCIENCE 104.2(2013):206-213.
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