北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies
作者: Wang, Junjie1; Yuan, Huishu2; Ma, Qingjun3; Liu, Xiaoguang3; Wang, Hao1; Jiang, Yuliang1; Tian, Suqing1; Yang, Ruijie1
关键词: I-125 seed implantation ; Spinal bone metastases ; Primary paraspinal malignancies ; CT-guidance
刊名: MEDICAL ONCOLOGY
发表日期: 2010-06-01
DOI: 10.1007/s12032-009-9212-1
卷: 27, 期:2, 页:319-326
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CORD COMPRESSION ; SURGICAL-MANAGEMENT ; RADIATION-THERAPY ; BRACHYTHERAPY ; CANCER ; TUMORS ; SURGERY
英文摘要:

Spinal cord metastatic malignances and locally invasive paraspinal carcinomas were severe pain and disabling complications. The treatment modality was unclear. We retrospectively evaluated the safety and efficacy of I-125 seed implantation for spinal metastatic and paraspinal malignancies in our center. A total of 19 patients and 22 procedures were included in this study. Eight patients received a seed implant in an operation, and 11 patients were implanted percutaneousely under CT-guidance. The number of I-125 seeds implanted ranged from 6 to 100, with a median of 26. The specific activity of I-125 seeds ranged from 0.45 to 0.80 mCi per seed, with a median of 0.5 mCi. The minimal peripheral doses of I-125 seed implantation were 90-140 Gy, with median of 120 Gy. Follow-up ranged from 3 to 69 months with a median of 22 months. All patients tolerated seed implantation well. The 1, 2, 3, and 5 year local control rates were 63%, 47%, 31%, and 3%, respectively, with a median of 22 months (3-61 months). The 1, 2, 3, and 5 year survival rates were 74%, 56%, 43%, and 43%, respectively, with a median of 33 months. Ten patients (52.6%) developed distant metastases. Two (10.5%) patients showed recurrence at 13 and 39 months. Seven (36.8%) patients were still alive, 84% (16/19) of patients had either normal or improved ambulation following seed implant. No myelopathies were encountered. Our study suggests a promising local therapy for a selected population of patients with spinal cord metastatic or paraspinal carcinoma.

语种: 英语
WOS记录号: WOS:000277203200024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56707
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Surg, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Junjie,Yuan, Huishu,Ma, Qingjun,et al. Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies[J]. MEDICAL ONCOLOGY,2010,27(2):319-326.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Junjie]'s Articles
[Yuan, Huishu]'s Articles
[Ma, Qingjun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Junjie]‘s Articles
[Yuan, Huishu]‘s Articles
[Ma, Qingjun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace