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学科主题: 临床医学
题名:
Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies
作者: Wang, Junjie1; Yuan, Huishu2; Ma, Qingjun3; Liu, Xiaoguang3; Wang, Hao1; Jiang, Yuliang1; Tian, Suqing1; Yang, Ruijie1
关键词: I-125 seed implantation ; Spinal bone metastases ; Primary paraspinal malignancies ; CT-guidance
刊名: MEDICAL ONCOLOGY
发表日期: 2010-06-01
DOI: 10.1007/s12032-009-9212-1
卷: 27, 期:2, 页:319-326
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CORD COMPRESSION ; SURGICAL-MANAGEMENT ; RADIATION-THERAPY ; BRACHYTHERAPY ; CANCER ; TUMORS ; SURGERY
英文摘要:

Spinal cord metastatic malignances and locally invasive paraspinal carcinomas were severe pain and disabling complications. The treatment modality was unclear. We retrospectively evaluated the safety and efficacy of I-125 seed implantation for spinal metastatic and paraspinal malignancies in our center. A total of 19 patients and 22 procedures were included in this study. Eight patients received a seed implant in an operation, and 11 patients were implanted percutaneousely under CT-guidance. The number of I-125 seeds implanted ranged from 6 to 100, with a median of 26. The specific activity of I-125 seeds ranged from 0.45 to 0.80 mCi per seed, with a median of 0.5 mCi. The minimal peripheral doses of I-125 seed implantation were 90-140 Gy, with median of 120 Gy. Follow-up ranged from 3 to 69 months with a median of 22 months. All patients tolerated seed implantation well. The 1, 2, 3, and 5 year local control rates were 63%, 47%, 31%, and 3%, respectively, with a median of 22 months (3-61 months). The 1, 2, 3, and 5 year survival rates were 74%, 56%, 43%, and 43%, respectively, with a median of 33 months. Ten patients (52.6%) developed distant metastases. Two (10.5%) patients showed recurrence at 13 and 39 months. Seven (36.8%) patients were still alive, 84% (16/19) of patients had either normal or improved ambulation following seed implant. No myelopathies were encountered. Our study suggests a promising local therapy for a selected population of patients with spinal cord metastatic or paraspinal carcinoma.

语种: 英语
WOS记录号: WOS:000277203200024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56707
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Surg, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Junjie,Yuan, Huishu,Ma, Qingjun,et al. Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies[J]. MEDICAL ONCOLOGY,2010,27(2):319-326.
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