IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科
学科主题临床医学
Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies
Wang, Junjie1; Yuan, Huishu2; Ma, Qingjun3; Liu, Xiaoguang3; Wang, Hao1; Jiang, Yuliang1; Tian, Suqing1; Yang, Ruijie1
关键词I-125 Seed Implantation Spinal Bone Metastases Primary Paraspinal Malignancies Ct-guidance
刊名MEDICAL ONCOLOGY
2010-06-01
DOI10.1007/s12032-009-9212-1
27期:2页:319-326
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CORD COMPRESSION ; SURGICAL-MANAGEMENT ; RADIATION-THERAPY ; BRACHYTHERAPY ; CANCER ; TUMORS ; SURGERY
英文摘要

Spinal cord metastatic malignances and locally invasive paraspinal carcinomas were severe pain and disabling complications. The treatment modality was unclear. We retrospectively evaluated the safety and efficacy of I-125 seed implantation for spinal metastatic and paraspinal malignancies in our center. A total of 19 patients and 22 procedures were included in this study. Eight patients received a seed implant in an operation, and 11 patients were implanted percutaneousely under CT-guidance. The number of I-125 seeds implanted ranged from 6 to 100, with a median of 26. The specific activity of I-125 seeds ranged from 0.45 to 0.80 mCi per seed, with a median of 0.5 mCi. The minimal peripheral doses of I-125 seed implantation were 90-140 Gy, with median of 120 Gy. Follow-up ranged from 3 to 69 months with a median of 22 months. All patients tolerated seed implantation well. The 1, 2, 3, and 5 year local control rates were 63%, 47%, 31%, and 3%, respectively, with a median of 22 months (3-61 months). The 1, 2, 3, and 5 year survival rates were 74%, 56%, 43%, and 43%, respectively, with a median of 33 months. Ten patients (52.6%) developed distant metastases. Two (10.5%) patients showed recurrence at 13 and 39 months. Seven (36.8%) patients were still alive, 84% (16/19) of patients had either normal or improved ambulation following seed implant. No myelopathies were encountered. Our study suggests a promising local therapy for a selected population of patients with spinal cord metastatic or paraspinal carcinoma.

语种英语
WOS记录号WOS:000277203200024
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56707
Collection北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Hosp 3, Dept Surg, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, Junjie,Yuan, Huishu,Ma, Qingjun,et al. Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies[J]. MEDICAL ONCOLOGY,2010,27(2):319-326.
APA Wang, Junjie.,Yuan, Huishu.,Ma, Qingjun.,Liu, Xiaoguang.,Wang, Hao.,...&Yang, Ruijie.(2010).Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies.MEDICAL ONCOLOGY,27(2),319-326.
MLA Wang, Junjie,et al."Interstitial I-125 seeds implantation to treat spinal metastatic and primary paraspinal malignancies".MEDICAL ONCOLOGY 27.2(2010):319-326.
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