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学科主题: 药学
题名:
Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate
作者: Yin, FL; Zou, JJ; Xu, L; Wang, X; Li, RC
关键词: lanthanum complex ; demethylcantharidate group ; antitumor activity ; rare earths
刊名: JOURNAL OF RARE EARTHS
发表日期: 2005-10-01
卷: 23, 期:5, 页:596-599
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied
研究领域[WOS]: Chemistry
关键词[WOS]: CYTOTOXICITY ; ACID
英文摘要:

A novel complex of lanthanum( III) with demethylcantharidate group (DCA), Na[ La(DCA)(2)(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, III, UV, H-1-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na(2)DCA in vitro.

语种: 英语
WOS记录号: WOS:000233064400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56712
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Yin, FL,Zou, JJ,Xu, L,et al. Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate[J]. JOURNAL OF RARE EARTHS,2005,23(5):596-599.
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