北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate
作者: Yin, FL; Zou, JJ; Xu, L; Wang, X; Li, RC
关键词: lanthanum complex ; demethylcantharidate group ; antitumor activity ; rare earths
刊名: JOURNAL OF RARE EARTHS
发表日期: 2005-10-01
卷: 23, 期:5, 页:596-599
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied
研究领域[WOS]: Chemistry
关键词[WOS]: CYTOTOXICITY ; ACID
英文摘要:

A novel complex of lanthanum( III) with demethylcantharidate group (DCA), Na[ La(DCA)(2)(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, III, UV, H-1-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na(2)DCA in vitro.

语种: 英语
WOS记录号: WOS:000233064400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56712
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Yin, FL,Zou, JJ,Xu, L,et al. Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate[J]. JOURNAL OF RARE EARTHS,2005,23(5):596-599.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yin, FL]'s Articles
[Zou, JJ]'s Articles
[Xu, L]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yin, FL]‘s Articles
[Zou, JJ]‘s Articles
[Xu, L]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace