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Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate
Yin, FL; Zou, JJ; Xu, L; Wang, X; Li, RC
关键词Lanthanum Complex Demethylcantharidate Group Antitumor Activity Rare Earths
刊名JOURNAL OF RARE EARTHS
2005-10-01
23期:5页:596-599
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied
研究领域[WOS]Chemistry
关键词[WOS]CYTOTOXICITY ; ACID
英文摘要

A novel complex of lanthanum( III) with demethylcantharidate group (DCA), Na[ La(DCA)(2)(H2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, III, UV, H-1-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)2(H2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na(2)DCA in vitro.

语种英语
WOS记录号WOS:000233064400018
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56712
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yin, FL,Zou, JJ,Xu, L,et al. Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate[J]. JOURNAL OF RARE EARTHS,2005,23(5):596-599.
APA Yin, FL,Zou, JJ,Xu, L,Wang, X,&Li, RC.(2005).Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate.JOURNAL OF RARE EARTHS,23(5),596-599.
MLA Yin, FL,et al."Synthesis, characterization and antitumor activity of lanthanum(III) complex with demethylcantharidate".JOURNAL OF RARE EARTHS 23.5(2005):596-599.
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