IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Orchitis: A complication of severe acute respiratory syndrome (SARS)
Xu, J; Qi, LH; Chi, XH; Yang, JJ; Wei, XH; Gong, EC; Peh, S; Gu, J
关键词immunohistochemistry in situ hybridization orchitis SARS spermatogenesis testis
刊名BIOLOGY OF REPRODUCTION
2006-02-01
DOI10.1095/biolreprod.105.044776
74期:2页:410-416
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Reproductive Biology
研究领域[WOS]Reproductive Biology
关键词[WOS]ACQUIRED IMMUNODEFICIENCY SYNDROME ; ANGIOTENSIN-CONVERTING ENZYME ; IMMUNE-DEFICIENCY-SYNDROME ; GERM-CELL TUMORS ; CORONAVIRUS ; TESTIS ; MEN ; HISTOPATHOLOGY ; PATHOGENESIS ; EXPRESSION
英文摘要

Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.

语种英语
WOS记录号WOS:000234816600023
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56716
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, J,Qi, LH,Chi, XH,et al. Orchitis: A complication of severe acute respiratory syndrome (SARS)[J]. BIOLOGY OF REPRODUCTION,2006,74(2):410-416.
APA Xu, J.,Qi, LH.,Chi, XH.,Yang, JJ.,Wei, XH.,...&Gu, J.(2006).Orchitis: A complication of severe acute respiratory syndrome (SARS).BIOLOGY OF REPRODUCTION,74(2),410-416.
MLA Xu, J,et al."Orchitis: A complication of severe acute respiratory syndrome (SARS)".BIOLOGY OF REPRODUCTION 74.2(2006):410-416.
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