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学科主题: 基础医学
题名:
Orchitis: A complication of severe acute respiratory syndrome (SARS)
作者: Xu, J; Qi, LH; Chi, XH; Yang, JJ; Wei, XH; Gong, EC; Peh, S; Gu, J
关键词: immunohistochemistry ; in situ hybridization ; orchitis ; SARS ; spermatogenesis ; testis
刊名: BIOLOGY OF REPRODUCTION
发表日期: 2006-02-01
DOI: 10.1095/biolreprod.105.044776
卷: 74, 期:2, 页:410-416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology
研究领域[WOS]: Reproductive Biology
关键词[WOS]: ACQUIRED IMMUNODEFICIENCY SYNDROME ; ANGIOTENSIN-CONVERTING ENZYME ; IMMUNE-DEFICIENCY-SYNDROME ; GERM-CELL TUMORS ; CORONAVIRUS ; TESTIS ; MEN ; HISTOPATHOLOGY ; PATHOGENESIS ; EXPRESSION
英文摘要:

Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.

语种: 英语
WOS记录号: WOS:000234816600023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56716
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, J,Qi, LH,Chi, XH,et al. Orchitis: A complication of severe acute respiratory syndrome (SARS)[J]. BIOLOGY OF REPRODUCTION,2006,74(2):410-416.
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