IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
Jia, Xinying1; Zhang, Hong1; Cao, Xu2; Yin, Yuxin1; Zhang, Bo1
关键词TRP channel Transient receptor potential vanilloid 1 Protease-activated receptor-2 Thymic stromal lymphopoietin Asthma Nuclear factor of activated T-cells
刊名FEBS LETTERS
2014-08-25
DOI10.1016/j.febslet.2014.06.018
588期:17页:3047-3054
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]CAPSAICIN RECEPTOR ; ATOPIC-DERMATITIS ; SENSORY NEURONS ; PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES ; ALLERGIC INFLAMMATION ; ION CHANNELS ; ASTHMA ; PROTEIN ; TRPA1 ; MICE
英文摘要

The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease-activated receptor (PAR)-2 activation is also partially mediated by TRPV1 channels. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000340882900040
项目编号2013T60044
资助机构China Postdoctoral Science Foundation
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56719
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jia, Xinying,Zhang, Hong,Cao, Xu,et al. Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells[J]. FEBS LETTERS,2014,588(17):3047-3054.
APA Jia, Xinying,Zhang, Hong,Cao, Xu,Yin, Yuxin,&Zhang, Bo.(2014).Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells.FEBS LETTERS,588(17),3047-3054.
MLA Jia, Xinying,et al."Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells".FEBS LETTERS 588.17(2014):3047-3054.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Activation of TRPV1 (1501KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jia, Xinying]的文章
[Zhang, Hong]的文章
[Cao, Xu]的文章
百度学术
百度学术中相似的文章
[Jia, Xinying]的文章
[Zhang, Hong]的文章
[Cao, Xu]的文章
必应学术
必应学术中相似的文章
[Jia, Xinying]的文章
[Zhang, Hong]的文章
[Cao, Xu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+ NFAT pathway in airway epithelial cells.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。