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学科主题: 基础医学
题名:
Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
作者: Jia, Xinying1; Zhang, Hong1; Cao, Xu2; Yin, Yuxin1; Zhang, Bo1
关键词: TRP channel ; Transient receptor potential vanilloid 1 ; Protease-activated receptor-2 ; Thymic stromal lymphopoietin ; Asthma ; Nuclear factor of activated T-cells
刊名: FEBS LETTERS
发表日期: 2014-08-25
DOI: 10.1016/j.febslet.2014.06.018
卷: 588, 期:17, 页:3047-3054
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: CAPSAICIN RECEPTOR ; ATOPIC-DERMATITIS ; SENSORY NEURONS ; PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES ; ALLERGIC INFLAMMATION ; ION CHANNELS ; ASTHMA ; PROTEIN ; TRPA1 ; MICE
英文摘要:

The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease-activated receptor (PAR)-2 activation is also partially mediated by TRPV1 channels. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2013T60044
项目资助者: China Postdoctoral Science Foundation
WOS记录号: WOS:000340882900040
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56719
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Jia, Xinying,Zhang, Hong,Cao, Xu,et al. Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells[J]. FEBS LETTERS,2014,588(17):3047-3054.
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