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学科主题: 临床医学
题名:
Myths and Facts About Heart Failure with Preserved Ejection Fraction: Risk Factors, Longevity, Potential Pharmacological and Exercise Interventions
作者: Hung, Chung-Lieh1,2,3; Hou, Charles Jia-Yin1,2,3; Hu, Gwo-Chi4; Kuo, Jen-Yuan2,5,6; Hsu, Chia-Yu4; Tsai, Cheng-Ho2; Yeh, Hung-I1,2; Bulwer, Bernard E.7,8; Hsieh, Ya-Ching9
关键词: aging ; diabetes ; heart failure ; HFpEF ; hypertension
刊名: INTERNATIONAL JOURNAL OF GERONTOLOGY
发表日期: 2013-03-01
DOI: 10.1016/j.ijge.2013.01.009
卷: 7, 期:1, 页:1-7
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology
研究领域[WOS]: Geriatrics & Gerontology
关键词[WOS]: VENTRICULAR SYSTOLIC FUNCTION ; QUALITY-OF-LIFE ; DIASTOLIC DYSFUNCTION ; LONG-TERM ; PULMONARY-HYPERTENSION ; MYOCARDIAL FIBROSIS ; CONSENSUS STATEMENT ; CLINICAL-FEATURES ; CARDIAC-FUNCTION ; ELDERLY-PATIENTS
英文摘要:

Significant progress in our understanding of risk factors and interventions in heart failure, a leading cause of death and disability, has occurred in recent years. Several advances in therapy for heart failure with reduced left ventricular systolic function (i.e., systolic heart failure) have led to significantly improved outcomes. Treatment options for diastolic heart failure, also known as heart failure with preserved ejection fraction (HFpEF), by contrast, remain comparatively limited. In part, this is due to gaps in our understanding of the underlying pathophysiology and the lack of standardized criteria for its diagnosis and classification. Aging and hypertension remain the leading causes of HFpEF; increased ventricular and vascular stiffness is a feature of both. Comorbidities such as diabetes, renal insufficiency, and metabolic abnormalities further aggravate disease process, and data regarding effective treatment are lacking. This article discusses the risks, mechanisms, and outcomes of HFpEF from previous studies, and summarizes potential interventions that may provide new insights into our understanding of the disease and its treatment. Copyright (C) 2013, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.

语种: 英语
WOS记录号: WOS:000317945800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56727
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Mackay Med Coll, New Taipei City 252, New Taipei Coun, Taiwan
2.Mackay Mem Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan
3.Mackay Med Nursing & Management Coll, Taipei, Taiwan
4.Mackay Mem Hosp, Dept Rehabil Med, Taipei, Taiwan
5.Vet Gen Hosp, Taipei, Taiwan
6.Massachusetts Coll Pharm & Hlth Sci, Boston, MA USA
7.Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA
8.Natl Yang Ming Univ, Sch Med, Dept Med, Div Cardiol, Taipei 112, Taiwan
9.Peking Univ, Hosp 1, Dept Anesthesia, Beijing 100871, Peoples R China

Recommended Citation:
Hung, Chung-Lieh,Hou, Charles Jia-Yin,Hu, Gwo-Chi,et al. Myths and Facts About Heart Failure with Preserved Ejection Fraction: Risk Factors, Longevity, Potential Pharmacological and Exercise Interventions[J]. INTERNATIONAL JOURNAL OF GERONTOLOGY,2013,7(1):1-7.
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