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学科主题口腔医学
Comorbid diseases of IgG4-related sialadenitis in the head and neck region
Hong, Xia1; Sun, Zhi-Peng2; Li, Wei1; Chen, Yan3; Gao, Yan3; Su, Jia-Zeng1; Wang, Zhen1; Cai, Zhi-Gang1; Li, Tong-Tong1; Zhang, Lei1; Liu, Xiao-Jing1; Liu, Yan-Ying4; He, Jing4; Li, Zhan-Guo4; Yu, Guang-Yan1
关键词Igg4-related Sialadenitis Comorbid Diseases Head And Neck Rhinosinusitis Lymphadenopathy Ocular Adnexa Salivary Gland
刊名LARYNGOSCOPE
2015-09-01
DOI10.1002/lary.25387
125期:9页:2113-2118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Otorhinolaryngology
研究领域[WOS]Research & Experimental Medicine ; Otorhinolaryngology
关键词[WOS]IMMUNOGLOBULIN G4-RELATED DISEASE ; AUTOIMMUNE PANCREATITIS ; LYMPH-NODES ; MANIFESTATIONS ; LYMPHADENOPATHY ; DACRYOADENITIS ; RHINOSINUSITIS ; ENLARGEMENT ; PREVALENCE ; LESIONS
英文摘要

Objectives/HypothesisTo further recognize the comorbid diseases of immunoglobulin G4-related sialadenitis (IgG4-RS) in the head and neck region and to observe the response of these conditions to immunomodulatory therapy.

Study DesignRetrospective review.

MethodsThe symptoms of comorbid diseases and medical histories in 51 patients (24 men, 27 women; median age, 55 years) diagnosed with IgG4-RS were analyzed. Thirty-six patients received immunomodulatory therapy and were followed up for 10.45.9 months. Computed tomography (CT) examination was performed before and after therapy.

ResultsRhinosinusitis occurred in 58.8% patients, and manifested with the symptoms of nasal obstruction, nasal xerosis, and hyposmia. In addition, 43.1% patients had allergic rhinitis. Lymphadenopathy was identified in 74.5% patients. Lacrimal gland swelling occurred in 78.4% patients. Extraocular muscles, otologic organs, skin and superficial soft tissue, and cranial nerves were also involved. All of the lesions were relieved after immunomodulatory therapy. The Lund-Mackay scores decreased (9.65.6 to 1.0 +/- 2.2) according to CT analyses (P<.05). Mean CT volumes of the swollen lymph nodes and lacrimal glands decreased from 1.21 +/- 0.61 cm(3) to 0.59 +/- 0.35 cm(3) and from 2.25 +/- 1.35 cm(3) to 0.70 +/- 0.32 cm(3), respectively (P < .05) after treatment.

ConclusionsIgG4-RS could potentially develop with involvement of ocular adnexa, sinonasal cavities, ears, lymph nodes, skin and superficial soft tissue, and cranial nerves in the head and neck region. Immunomodulatory therapy could be effective in controlling both the comorbid diseases of IgG4-RS and sialadenitis of the major salivary glands.

Level of Evidence4 Laryngoscope, 125:2113-2118, 2015

语种英语
WOS记录号WOS:000360231700028
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56728
专题北京大学口腔医学院_医学影像科
北京大学第二临床医学院_风湿免疫科
北京大学口腔医学院_口腔放射科
北京大学口腔医学院_外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100081, Peoples R China
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GB/T 7714
Hong, Xia,Sun, Zhi-Peng,Li, Wei,et al. Comorbid diseases of IgG4-related sialadenitis in the head and neck region[J]. LARYNGOSCOPE,2015,125(9):2113-2118.
APA Hong, Xia.,Sun, Zhi-Peng.,Li, Wei.,Chen, Yan.,Gao, Yan.,...&Yu, Guang-Yan.(2015).Comorbid diseases of IgG4-related sialadenitis in the head and neck region.LARYNGOSCOPE,125(9),2113-2118.
MLA Hong, Xia,et al."Comorbid diseases of IgG4-related sialadenitis in the head and neck region".LARYNGOSCOPE 125.9(2015):2113-2118.
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