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IR@PKUHSC  > 北京大学口腔医学院  > 医学影像科  > 期刊论文
学科主题: 口腔医学
题名:
Comorbid diseases of IgG4-related sialadenitis in the head and neck region
作者: Hong, Xia1; Sun, Zhi-Peng2; Li, Wei1; Chen, Yan3; Gao, Yan3; Su, Jia-Zeng1; Wang, Zhen1; Cai, Zhi-Gang1; Li, Tong-Tong1; Zhang, Lei1; Liu, Xiao-Jing1; Liu, Yan-Ying4; He, Jing4; Li, Zhan-Guo4; Yu, Guang-Yan1
关键词: IgG4-related sialadenitis ; comorbid diseases ; head and neck ; rhinosinusitis ; lymphadenopathy ; ocular adnexa ; salivary gland
刊名: LARYNGOSCOPE
发表日期: 2015-09-01
DOI: 10.1002/lary.25387
卷: 125, 期:9, 页:2113-2118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Otorhinolaryngology
研究领域[WOS]: Research & Experimental Medicine ; Otorhinolaryngology
关键词[WOS]: IMMUNOGLOBULIN G4-RELATED DISEASE ; AUTOIMMUNE PANCREATITIS ; LYMPH-NODES ; MANIFESTATIONS ; LYMPHADENOPATHY ; DACRYOADENITIS ; RHINOSINUSITIS ; ENLARGEMENT ; PREVALENCE ; LESIONS
英文摘要:

Objectives/HypothesisTo further recognize the comorbid diseases of immunoglobulin G4-related sialadenitis (IgG4-RS) in the head and neck region and to observe the response of these conditions to immunomodulatory therapy.

Study DesignRetrospective review.

MethodsThe symptoms of comorbid diseases and medical histories in 51 patients (24 men, 27 women; median age, 55 years) diagnosed with IgG4-RS were analyzed. Thirty-six patients received immunomodulatory therapy and were followed up for 10.45.9 months. Computed tomography (CT) examination was performed before and after therapy.

ResultsRhinosinusitis occurred in 58.8% patients, and manifested with the symptoms of nasal obstruction, nasal xerosis, and hyposmia. In addition, 43.1% patients had allergic rhinitis. Lymphadenopathy was identified in 74.5% patients. Lacrimal gland swelling occurred in 78.4% patients. Extraocular muscles, otologic organs, skin and superficial soft tissue, and cranial nerves were also involved. All of the lesions were relieved after immunomodulatory therapy. The Lund-Mackay scores decreased (9.65.6 to 1.0 +/- 2.2) according to CT analyses (P<.05). Mean CT volumes of the swollen lymph nodes and lacrimal glands decreased from 1.21 +/- 0.61 cm(3) to 0.59 +/- 0.35 cm(3) and from 2.25 +/- 1.35 cm(3) to 0.70 +/- 0.32 cm(3), respectively (P < .05) after treatment.

ConclusionsIgG4-RS could potentially develop with involvement of ocular adnexa, sinonasal cavities, ears, lymph nodes, skin and superficial soft tissue, and cranial nerves in the head and neck region. Immunomodulatory therapy could be effective in controlling both the comorbid diseases of IgG4-RS and sialadenitis of the major salivary glands.

Level of Evidence4 Laryngoscope, 125:2113-2118, 2015

语种: 英语
WOS记录号: WOS:000360231700028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56728
Appears in Collections:北京大学口腔医学院_医学影像科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100081, Peoples R China

Recommended Citation:
Hong, Xia,Sun, Zhi-Peng,Li, Wei,et al. Comorbid diseases of IgG4-related sialadenitis in the head and neck region[J]. LARYNGOSCOPE,2015,125(9):2113-2118.
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