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Antcamphins A-L, Ergostanoids from Antrodia camphorata
Huang, Yun1; Lin, Xionghao1; Qiao, Xue1; Ji, Shuai1; Liu, Kedi1; Yeh, Chi-tai2; Tzeng, Yew-min3; Guo, Dean1; Ye, Min1
刊名JOURNAL OF NATURAL PRODUCTS
2014
DOI10.1021/np400741s
77期:1页:118-124
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]CINNAMOMUM MICRANTHUM ; TRITERPENOIDS
英文摘要

Twelve ergostanoids, named antcamphins A L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher′s method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

语种英语
WOS记录号WOS:000330336800018
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56732
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Taipei Med Univ, Grad Inst Clin Med, Taipei 11031, Taiwan
3.Chaoyang Univ Technol, Inst Biochem Sci & Technol, Taichung 41349, Taiwan
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GB/T 7714
Huang, Yun,Lin, Xionghao,Qiao, Xue,et al. Antcamphins A-L, Ergostanoids from Antrodia camphorata[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):118-124.
APA Huang, Yun.,Lin, Xionghao.,Qiao, Xue.,Ji, Shuai.,Liu, Kedi.,...&Ye, Min.(2014).Antcamphins A-L, Ergostanoids from Antrodia camphorata.JOURNAL OF NATURAL PRODUCTS,77(1),118-124.
MLA Huang, Yun,et al."Antcamphins A-L, Ergostanoids from Antrodia camphorata".JOURNAL OF NATURAL PRODUCTS 77.1(2014):118-124.
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