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学科主题: 药学
题名:
Antcamphins A-L, Ergostanoids from Antrodia camphorata
作者: Huang, Yun1; Lin, Xionghao1; Qiao, Xue1; Ji, Shuai1; Liu, Kedi1; Yeh, Chi-tai2; Tzeng, Yew-min3; Guo, Dean1; Ye, Min1
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014
DOI: 10.1021/np400741s
卷: 77, 期:1, 页:118-124
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: CINNAMOMUM MICRANTHUM ; TRITERPENOIDS
英文摘要:

Twelve ergostanoids, named antcamphins A L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher′s method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

语种: 英语
所属项目编号: 81222054 ; 81303294 ; NCET-11-0019 ; NSC 100-2113-M-324-001-MY3
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from Chinese Ministry of Education ; National Science Council of Taiwan
WOS记录号: WOS:000330336800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56732
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Taipei Med Univ, Grad Inst Clin Med, Taipei 11031, Taiwan
3.Chaoyang Univ Technol, Inst Biochem Sci & Technol, Taichung 41349, Taiwan

Recommended Citation:
Huang, Yun,Lin, Xionghao,Qiao, Xue,et al. Antcamphins A-L, Ergostanoids from Antrodia camphorata[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):118-124.
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