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学科主题: 临床医学
题名:
Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells
作者: Ren, YaLi; Xie, YanLing; Chai, LiJun; Wang, ShuHe; Cheng, Ming
关键词: Autophagy ; Rapamycin ; 3-Methyladenine ; NB4 ; Ultrastructure
刊名: MEDICAL ONCOLOGY
发表日期: 2011-03-01
DOI: 10.1007/s12032-010-9430-6
卷: 28, 期:1, 页:231-236
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ACUTE PROMYELOCYTIC LEUKEMIA ; TUMOR-SUPPRESSOR ; CANCER-CELLS ; DEATH ; BECLIN-1 ; TUMORIGENESIS ; RADIATION ; APOPTOSIS ; INDUCTION ; RESPONSES
英文摘要:

Autophagy is a survival pathway required for cellular viability during starvation through catabolic self-digestion of damaged proteins and organelles; however, autophagy may result in cell death if it proceeds to completion. Although the exact mechanism of this process is not clear, it seems that proper regulation of autophagy can potentially contribute to the therapeutics of cancers. This study was designed to examine the role of autophagy in the death of human acute promyelocytic leukemia NB4 cells initiated by arsenic trioxide. Furthermore, the effects of autophagy inhibition and augmentation on cell viability were also compared. Our data suggested that both augmentation and suppression of autophagy could enhance the treatment effects while the latter was preferable. This study indicated that autophagy regulation augmented the treatment effects initiated by arsenic trioxide in NB4 cells, and that the selection of regulator should be precisely considered.

语种: 英语
WOS记录号: WOS:000287756000036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56737
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Lab Electron Microscopy, Beijing 100034, Peoples R China

Recommended Citation:
Ren, YaLi,Xie, YanLing,Chai, LiJun,et al. Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells[J]. MEDICAL ONCOLOGY,2011,28(1):231-236.
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