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学科主题: 临床医学
题名:
Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis
作者: Liu, G. -z.; Gomes, A. C.; Putheti, P.; Karrenbauer, V.; Kostulas, K.; Press, R.; Hillert, J.; Hjelmstrom, P.; Gao, X. -G.
刊名: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
发表日期: 2006-10-01
DOI: 10.1111/j.1365-3083.2006.01796.x
卷: 64, 期:4, 页:412-419
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: MYELIN BASIC-PROTEIN ; TUMOR-NECROSIS-FACTOR ; CD28(-) T-CELLS ; MONONUCLEAR-CELLS ; DENDRITIC CELLS ; RHEUMATOID-ARTHRITIS ; SUPERFAMILY LIGANDS ; REGULATORY FUNCTION ; IMMUNE-RESPONSES ; CD137 ILA/4-1BB
英文摘要:

4-1BB ligand (4-1BBL; CD137L) is a member of the tumour necrosis factor superfamily expressed primarily on antigen presenting cells such as B cells, macrophages and dendritic cells. Its engagement with the receptor 4-1BB (CD137) has been shown to promote T-cell activation and regulate proliferation and survival of T cells. The role of the costimulatory molecule in multiple sclerosis (MS) remains unclear. In this study, the expression of 4-1BBL and soluble 4-1BBL (s4-1BBL) protein levels were analysed in peripheral blood of MS patients. Compared with healthy controls, MS patients had an increase in both plasma s4-1BBL protein levels and expression of 4-1BBL in CD14+ monocytes. In contrast, myelin basic protein-reactive T-cell proliferation was not found to be inhibited by the use of an anti-4-1BBL antibody. The elevated s4-1BBL protein levels in the MS patients may function as a self-regulatory mechanism of 4-1BB/4-1BBL interaction and costimulation.

语种: 英语
WOS记录号: WOS:000240529400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56742
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Karolinska Inst, Dept Clin Neurosci, Div Neurol, Stockholm, Sweden
3.Karolinska Inst, Neurotec Dept, Div Neuroimmunol, Stockholm, Sweden
4.Karolinska Inst, Dept Clin Sci, Stockholm, Sweden

Recommended Citation:
Liu, G. -z.,Gomes, A. C.,Putheti, P.,et al. Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2006,64(4):412-419.
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