北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肾内科  > 期刊论文
学科主题: 临床医学
题名:
End-stage kidney disease due to Alport syndrome: outcomes in 296 consecutive Australia and New Zealand Dialysis and Transplant Registry cases
作者: Mallett, Andrew1,2,3; Tang, Wen4; Clayton, Philip A.1,5,6; Stevenson, Sarah1,2; McDonald, Stephen P.1,7,8; Hawley, Carmel M.1,2; Badve, Sunil V.1,2; Boudville, Neil1,9; Brown, Fiona G.1,10; Campbell, Scott B.1,2; Johnson, David W.1,2
关键词: Alport syndrome ; dialysis ; hereditary nephritis ; outcomes ; renal transplantation
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2014-12-01
DOI: 10.1093/ndt/gfu254
卷: 29, 期:12, 页:2277-2286
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: ANTI-ALPHA-3(IV) COLLAGEN ALLOANTIBODIES ; GENOTYPE-PHENOTYPE CORRELATIONS ; ANTI-GBM NEPHRITIS ; RENAL-TRANSPLANTATION ; NATURAL-HISTORY ; HEREDITARY NEPHRITIS ; AUTOSOMAL-DOMINANT ; CLINICAL SPECTRUM ; 195 FAMILIES ; COL4A5 GENE
英文摘要:

Alport syndrome is a rare inheritable renal disease. Clinical outcomes for patients progressing to end-stage kidney disease (ESKD) are not well described.

This study aimed to investigate the characteristics and clinical outcomes of patients from Australia and New Zealand commencing renal replacement therapy (RRT) for ESKD due to Alport syndrome between 1965 and 1995 (early cohort) and between 1996 and 2010 (contemporary cohort) compared with propensity score-matched, RRT-treated, non-Alport ESKD controls.

A total of 58 422 patients started RRT during this period of which 296 (0.5%) patients had Alport ESKD. In the early cohort, Alport ESKD was associated with superior dialysis patient survival [adjusted hazard ratio (HR): 0.41, 95% confidence interval (CI): 0.20-0.83, P = 0.01], renal allograft survival (HR: 0.74, 95% CI: 0.54-1.01, P = 0.05) and renal transplant patient survival (HR: 0.43, 95% CI: 0.28-0.66, P < 0.001) compared with controls. In the contemporary cohort, no differences were observed between the two groups for dialysis patient survival (HR: 1.42, 95% CI: 0.65-3.11, P = 0.38), renal allograft survival (HR: 1.01, 95% CI: 0.57-1.79, P = 0.98) or renal transplant patient survival (HR: 0.67, 95% CI: 0.26-1.73, P = 0.41). One Alport patient (0.4%) had post-transplant anti-glomerular basement membrane (anti-GBM) disease. Four female and 41 male Alport patients became parents on RRT with generally good neonatal outcomes.

Alport syndrome patients experienced comparable dialysis and renal transplant outcomes to matched non-Alport ESKD controls in the contemporary cohort due to relatively greater improvements in outcomes for non-Alport ESKD patients over time. Post-transplant anti-GBM disease was rare.

语种: 英语
项目资助者: Baxter Healthcare Pty Ltd ; Fresenius Medical Care ; Queensland Government Health Research Fellowship ; Winston Churchill Memorial Trust Fellowship ; Amgen ; Royal Brisbane and Women&prime ; s Hospital Foundation Postgraduate Scholarship ; Roche ; Jansen Cilag
WOS记录号: WOS:000345833500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56744
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.ANZDATA Registry, Adelaide, SA, Australia
2.Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld 4102, Australia
3.Royal Brisbane & Womens Hosp, Dept Renal Med, Brisbane, Qld, Australia
4.Royal Prince Alfred Hosp, Dept Renal Med, Sydney, NSW, Australia
5.Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia
6.Monash Med Ctr, Dept Nephrol, Melbourne, Vic, Australia
7.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
8.Univ Adelaide, Dept Nephrol & Transplantat Serv, Adelaide, SA, Australia
9.Cent Northern Adelaide Renal & Transplantat Serv, Adelaide, SA, Australia
10.Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Perth, WA 6009, Australia

Recommended Citation:
Mallett, Andrew,Tang, Wen,Clayton, Philip A.,et al. End-stage kidney disease due to Alport syndrome: outcomes in 296 consecutive Australia and New Zealand Dialysis and Transplant Registry cases[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2014,29(12):2277-2286.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mallett, Andrew]'s Articles
[Tang, Wen]'s Articles
[Clayton, Philip A.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mallett, Andrew]‘s Articles
[Tang, Wen]‘s Articles
[Clayton, Philip A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace