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学科主题: 口腔医学
题名:
Phenylephrine protects autotransplanted rabbit submandibular gland from apoptosis
作者: Xiang, Bin3,4; Zhang, Yan1,2; Li, Yu-Ming1,2; Gao, Yan5; Gan, Ye-Hua4,6; Wu, Li-Ling1,2; Yu, Guang-Yan3
关键词: Submandibular gland transplantation ; Phenylephrine ; Apoptosis ; Bcl-2/Bax ; Caspase-3 ; p38 mitogen-activated protein kinase
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2008-12-05
DOI: 10.1016/j.bbrc.2008.09.120
卷: 377, 期:1, 页:210-214
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ISCHEMIA-REPERFUSION INJURY ; CANINE LUNG TRANSPLANTATION ; KERATOCONJUNCTIVITIS SICCA ; KINASE INHIBITOR ; ENDOTHELIAL-CELL ; DEATH ; LIVER
英文摘要:

Submandibular gland (SMG) autotransplantation is an effective treatment for severe keratoconjunctivitis sicca. Out previous studies have shown that phenylephrine attenuates structural injury and promotes cell proliferation in autotransplanted rabbit SMG. However, the mechanism by which phenylephrine to inhibit the injury has not been fully evaluated. In this study, we investigate the ability of phenylephrine to inhibit apoptosis in autotransplanted rabbit SMG. We observed that apoptosis occured in the early phase of SMG transplantation and that phenylephrine treatment protected transplanted SMG from apoptosis. Furthermore, we found that phenylephrine could significantly upregulate the expression of Bcl-2, downregulate the expression of Bax, and inhibit the activation of both caspase-3 and p38 mitogen-activated protein kinase in autotransplanted SMG. Therefore, the cytoprotective effects of phenylephrine on autotransplanted SMG may be a novel clinical strategy for autotransplanted SMG protection during the early post-operative stage of transplantation. (C) 2008 Elsevier Inc. All rights reserved

语种: 英语
所属项目编号: 30640093 ; 30730102 ; 2007BA118B11 ; 2005-2009 ; 0302 191 ; 2008026
项目资助者: National Natural Science Foundation of China ; National Key Technologies RD Program ; Foundation for Capital Medical Development ; Program for Changjiang Scholars and Innovative Research Team in University ; Science and Technology Project of Dalian University ; University Scientific Research Project of Educational Department of Liaoning Province
WOS记录号: WOS:000260738500041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56754
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Dalian Univ, Coll Med, Dept Oral Med, Dalian 116622, Liaoning, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
6.Peking Univ, Sch & Hosp Stomatol, Cent Res Lab, Beijing 100081, Peoples R China

Recommended Citation:
Xiang, Bin,Zhang, Yan,Li, Yu-Ming,et al. Phenylephrine protects autotransplanted rabbit submandibular gland from apoptosis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,377(1):210-214.
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