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学科主题: 临床医学
题名:
Helicobacter pylori infection in association with cell proliferation, apoptosis and prostaglandin E-2 levels
作者: Pan Kai-feng; Zhang Yang; Zhang Lian; Ma Jun-ling; Feng Guo-shuang; Zhou Tong; You Wei-cheng
关键词: Helicobacter pylori ; gastric cancer ; cell proliferation ; apoptosis ; PGE2
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2007-12-01
DOI: 10.1007/s11670-007-0249-4
卷: 19, 期:4, 页:249-254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PRECANCEROUS GASTRIC-LESIONS ; HIGH-RISK ; INTESTINAL METAPLASIA ; CHINESE POPULATION ; CANCER ; CYCLOOXYGENASE-2 ; CARCINOGENESIS ; CLASSIFICATION ; ERADICATION ; EXPRESSION
英文摘要:

Objective: To evaluate the relationship between H. pylori infection with cell proliferation, apoptosis and PGE2 levels. Methods: A population-based study was conducted in Linqu, a high-risk area of gastric cancer in China. A total of 1523 subjects, aged 35-64, participating in a gastric cancer screening survey were investigated. H. pylori status were determined by C-13-urea breath test, expressions of Ki-67 were assessed by immunohistochemistry, apoptotic cells were detected by terminal deoxynucleotide transferase mediated dUTP nick end-labeling ( TUNEL) method, and PGE2 levels were measured by enzyme immunoassay. Results: H. pylori infection was positively associated with cell proliferation activity. The mean and median percentage of Ki-67 labeling index ( LI) in subjects with H. pylori positive were 14.1 +/- 10.3 and 12.0, significantly higher than those with H. pylori negative ((x) over bar +/- s: 8.4 +/- 7.0; median: 5.8; P< 0.0001). Moreover, the prevalence rates of H. pylori infection showed a tendency to increase according to severity score of cell apoptosis ( P-trend < 0.0001), from score 0 to 3, the percentage of H. pylori positivity increased from 67.5% to 96.7%. Furthermore, The mean and median of PGE2 concentration were 628.84 +/- 726.40 pg/mL and 411.33 pg/mL among subjects with H. pylori positive compared with 658.19 +/- 575.91pg/mL and 455.97 pg/mL among those with H. pylori negative ( P= 0.209). Conclusion: H. pylori infection was positively associated with increased cell proliferation and apoptosis activity, suggesting that H. pylori infection plays an important role in the gastric epithelial cell malignant transformation.

语种: 英语
WOS记录号: WOS:000254851000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56756
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Beijing Univ, Sch Oncol, Beijing Inst Canc Res, Dept Canc Epidemiol,Beijing Canc Hosp, Beijing 100036, Peoples R China

Recommended Citation:
Pan Kai-feng,Zhang Yang,Zhang Lian,et al. Helicobacter pylori infection in association with cell proliferation, apoptosis and prostaglandin E-2 levels[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(4):249-254.
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