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学科主题基础医学
Effects of microgravity and hypergravity on platelet functions
Dai, Kesheng1; Wang, Yuedan2; Yan, Rong1; Shi, Quanwei1; Wang, Zhicheng1; Yuan, Yanhong1,3; Cheng, Hong1; Li, Suping1; Fan, Yubo1; Zhuang, Fengyuan1
关键词Platelets thrombosis haemorrhage simulated microgravity hypergravity
刊名THROMBOSIS AND HAEMOSTASIS
2009-05-01
DOI10.1160/TH08-11-0750
101期:5页:902-910
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]VON-WILLEBRAND-FACTOR ; GLYCOPROTEIN-IB-ALPHA ; ROLLER-COASTER RIDE ; MYOCARDIAL-INFARCTION ; MONOCLONAL-ANTIBODY ; COMPLEX ; PROTEIN ; IX ; ACTIVATION ; CELLS
英文摘要

Many serious thrombotic and haemorrhagic diseases or fatalities have been documented in human being exposed to microgravity or hypergravity environments, such as crewmen in space, roller coaster riders, and aircrew subjected to high-G training. Some possible related organs have been examined to explore the mechanisms underlying these gravity change-related diseases. However, the role of platelets which are the primary players in both thrombosis and haemostasis is unknown. Here we show that platelet aggregation induced by ristocetin or collagen and platelet adhesion to von Willebrand factor (VWF) were significantly decreased after platelets were exposed to simulated microgravity. Conversely, these platelet functions were increased after platelets were exposed to hypergravity. The tail bleeding time in vivo was significantly shortened in mice exposed to high-G force, whereas, was prolonged in hindlimb un-loaded mice. Furthermore, three of 23 mice died after IS minutes of -8 Gx stress. Platelet thrombi disseminated in the heart ventricle and blood vessels in the brain, lung, and heart from the dead mice. Finally, glycoprotein (GP) Ib alpha surface expression and its association with the cytoskeleton were significantly decreased in platelets exposed to simulated microgravity, and obviously increased in hype rgravity-exposed platelets. These data indicate that the platelet functions are inhibited in microgravity environments, and activated under high-G conditions, suggesting a novel mechanism for gravity change-related haemorrhagic and thrombotic diseases. This mechanism has important implications for preventing and treating gravity change-related diseases, and also suggests that special attentions should be paid to human actions under different gravity conditions.

语种英语
WOS记录号WOS:000266148300019
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56757
专题基础医学院_免疫学系
作者单位1.Peking Univ, Dept Immunol, Beijing 100871, Peoples R China
2.Beijing Univ Aeronaut & Astronaut, Dept Biol Sci & Technol, Beijing 100083, Peoples R China
3.China Astronaut Res & Training Ctr, Space Cell & Mol Biol Lab, Beijing, Peoples R China
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GB/T 7714
Dai, Kesheng,Wang, Yuedan,Yan, Rong,et al. Effects of microgravity and hypergravity on platelet functions[J]. THROMBOSIS AND HAEMOSTASIS,2009,101(5):902-910.
APA Dai, Kesheng.,Wang, Yuedan.,Yan, Rong.,Shi, Quanwei.,Wang, Zhicheng.,...&Zhuang, Fengyuan.(2009).Effects of microgravity and hypergravity on platelet functions.THROMBOSIS AND HAEMOSTASIS,101(5),902-910.
MLA Dai, Kesheng,et al."Effects of microgravity and hypergravity on platelet functions".THROMBOSIS AND HAEMOSTASIS 101.5(2009):902-910.
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