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学科主题: 药学
题名:
A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation
作者: Wang, YH; Yan, QY; Wu, JP; Zhang, LH; Ye, XS
关键词: alpha-galactosyl epitopes ; one-pot synthesis ; glycosylations ; oligosaccharides ; xenotransplantation
刊名: TETRAHEDRON
发表日期: 2005-04-25
DOI: 10.1016/j.tet.2005.02.023
卷: 61, 期:17, 页:4313-4321
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: OLIGOSACCHARIDE SYNTHESIS ; CHEMOSELECTIVE GLYCOSYLATIONS ; INTRAVENOUS-INFUSION ; GALACTOSYL EPITOPES ; THIOGLYCOSIDES ; TRISACCHARIDE ; REACTIVITY ; ANTIBODIES ; PENTASACCHARIDE ; EXPRESSION
英文摘要:

Xenotransplantations from pig to human are rapidly rejected because of the interaction between alpha-Gal epitopes carried by the graft and natural antibodies (anti-Gal antibodies) present in the blood of the recipient. This paper describes a three-component one-pot synthesis of three alpha-Gal related oligosaccharides with minimal protecting group manipulations in a very short period of time. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228417100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56758
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, YH,Yan, QY,Wu, JP,et al. A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation[J]. TETRAHEDRON,2005,61(17):4313-4321.
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