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A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation
Wang, YH; Yan, QY; Wu, JP; Zhang, LH; Ye, XS
关键词Alpha-galactosyl Epitopes One-pot Synthesis Glycosylations Oligosaccharides Xenotransplantation
刊名TETRAHEDRON
2005-04-25
DOI10.1016/j.tet.2005.02.023
61期:17页:4313-4321
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]OLIGOSACCHARIDE SYNTHESIS ; CHEMOSELECTIVE GLYCOSYLATIONS ; INTRAVENOUS-INFUSION ; GALACTOSYL EPITOPES ; THIOGLYCOSIDES ; TRISACCHARIDE ; REACTIVITY ; ANTIBODIES ; PENTASACCHARIDE ; EXPRESSION
英文摘要

Xenotransplantations from pig to human are rapidly rejected because of the interaction between alpha-Gal epitopes carried by the graft and natural antibodies (anti-Gal antibodies) present in the blood of the recipient. This paper describes a three-component one-pot synthesis of three alpha-Gal related oligosaccharides with minimal protecting group manipulations in a very short period of time. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228417100012
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56758
专题北京大学药学院
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, YH,Yan, QY,Wu, JP,et al. A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation[J]. TETRAHEDRON,2005,61(17):4313-4321.
APA Wang, YH,Yan, QY,Wu, JP,Zhang, LH,&Ye, XS.(2005).A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation.TETRAHEDRON,61(17),4313-4321.
MLA Wang, YH,et al."A new one-pot synthesis of alpha-Gal epitope derivatives involved in the hyperacute rejection response in xenotransplantation".TETRAHEDRON 61.17(2005):4313-4321.
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